微泡超声造影剂生物分析方法及药代动力学研究进展  

Advances in bioanalysis methods and pharmacokinetics of microbubble ultrasound contrast agents

作　　者：陈梓欣 陈西敬 赵娣 CHEN Zi-xin;CHEN Xi-jing;ZHAO Di(Clinical Pharmacology Research Center,School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198)

机构地区：[1]中国药科大学基础医学与临床药学学院临床药理研究中心,南京211198

出　　处：《中南药学》2024年第8期2070-2076,共7页Central South Pharmacy

摘　　要：微泡超声造影剂是一类能够显著增强医学超声检测信号的药物,常用于心脏、肝脏、肾脏等部位的超声检查。优化对比增强成像、提高诊断效率需要对体内微泡造影剂的药代动力学有全面了解。本文归纳总结了微泡超声造影剂常用生物分析方法及其药代动力学进展,系统阐释微泡超声造影剂在体内的吸收、分布、代谢和排泄过程,以期能够为微泡类药物的研究提供参考。Microbubble ultrasound contrast agent is a kind of drug that can significantly enhance the medical ultrasonic detection signal,and is often used in the ultrasonic examination of the heart,liver,kidney and other parts.Optimizing contrast enhancement imaging and improving diagnostic efficiency require a comprehensive understanding of the pharmacokinetics of microbubble contrast agents in vivo.In this paper,the commonly used biological analysis methods and pharmacokinetic progress of microbubble ultrasound contrast agents were summarized,and the absorption,distribution,metabolism and excretion processes of microbubble ultrasound contrast agents in vivo were systematically explained,hoping to provide references for the research of microbubble drugs.

关 键 词：微泡超声造影剂 药物代谢动力学 生物分析方法 

分 类 号：R981[医药卫生—药品]