银杏叶提取物联合地塞米松治疗突发性聋患者的效果  

Effects of Ginkgo biloba extract combined with Dexamethasone in treatment of patients with sudden deafness

作　　者：王海玲[1] WANG Haiing(Department of Otorhinolaryngology of the Second People’s Hospital of Jiyuan,Jiyuan 459000 Henan,China)

机构地区：[1]济源市第二人民医院耳鼻喉科,河南济源459000

出　　处：《中国民康医学》2024年第16期38-40,44,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察银杏叶提取物联合地塞米松治疗突发性聋患者的效果。方法:选取2020年8月至2023年8月该院收治的82例突发性聋患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各41例。对照组采用地塞米松治疗,研究组在对照组基础上联合银杏叶提取物治疗,比较两组临床疗效、临床症状(耳鸣耳闷、恶心呕吐、眩晕)消失时间、治疗前后纯音听阈值、氧化应激指标[内皮素(ET)、一氧化氮(NO)、可溶性血管细胞间黏附因子-1(sVCAM-1)]水平、血液流变学指标[血浆黏度(PV)、纤维蛋白原(FIB)、全血低切黏度(LBV)]水平以及不良反应发生率。结果:研究组治疗总有效率为95.12%,高于对照组的78.05%,差异有统计学意义(P<0.05);治疗后,两组1 kHz、2 kHz、4 kHz的纯音听阈值均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组耳鸣耳闷、恶心呕吐和眩晕等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组ET、sVCAM-1水平均低于治疗前,且研究组低于对照组,两组NO水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组PV、FIB和LBV水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合地塞米松治疗突发性聋患者可提高治疗总有效率,缩短临床症状消失时间,改善氧化应激指标水平,降低纯音听阈值和血液流变学指标水平,其效果优于单纯地塞米松治疗。Objective:To observe effects of Ginkgo biloba extract combined with Dexamethasone in treatment of patients with sudden deafness.Methods:A prospective study was conducted on 82 patients with sudden deafness admitted to the hospital from August 2020 to August 2023.According to the random number table method,they were divided into study group and control group,41 cases in each group.The control group was treated with Dexamethasone,while the study group was treated with Ginkgo biloba extract on the basis of that of the control group.The clinical efficacy,the pure tone hearing threshold values before and after the treatment,the disappearance time of clinical symptoms(tinnitus and ear fullness,nausea and vomiting,dizziness and vertigo),the levels of oxidative stress indexes[endothelin(ET),nitric oxide(NO),soluble vascular cell adhesion factor-1(sVCAM-1)],the levels of hemorheology indexes[plasma viscosity(PV),fibrinogen(FIB),whole blood low shear viscosity(LBV)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.12%,which was higher than 78.05%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the pure tone hearing threshold values at 1 kHz,2 kHz and 4 kHz in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The disappearance time of clinical symptoms such as tinnitus,nausea and vomiting,dizziness and vertigo in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of ET and sVCAM-1 in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the levels of NO in the two groups were higher than those before the treatment,and that in the study group was higher than that in the cont

关 键 词：银杏叶提取物 地塞米松 突发性聋 纯音听阈值 血液流变学 氧化应激 不良反应 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]