鳖甲煎丸联合阿德福韦酯治疗乙型肝炎肝硬化患者的效果  

Effects of Biejiajian pills combined with Adefovir dipivoxil in treatment of patients with hepatitis B cirrhosis

作　　者：颜岩 YAN Yan(Department of Gastroenterology of Ruzhou First People’s Hospital,Ruzhou 467500 Henan,China)

机构地区：[1]汝州市第一人民医院消化内科,河南汝州467500

出　　处：《中国民康医学》2024年第16期109-112,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察鳖甲煎丸联合阿德福韦酯治疗乙型肝炎肝硬化患者的效果。方法:选取2020年5月至2023年5月该院收治的86例乙型肝炎肝硬化患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各43例。对照组采用阿德福韦酯治疗,研究组在对照组基础上联合鳖甲煎丸治疗,比较两组临床疗效,治疗前后中医证候积分、肝功能指标[总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)]水平、肝纤维化指标[IV型胶原蛋白(C-IV)、层粘连蛋白(LN)、透明质酸(HA)]水平、T细胞亚群指标水平,以及不良反应发生率。结果:研究组治疗总有效率为95.35%(41/43),高于对照组的79.07%(34/43),差异有统计学意义(P<0.05);治疗后,两组腹大胀满、纳少神疲、胁腹攻痛等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组TBIL、ALT、AST水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组C-IV、LN、HA水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组CD3^(+)、CD4^(+)水平均高于治疗前,且研究组高于对照组,两组+CD8水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:鳖甲煎丸联合阿德福韦酯治疗乙型肝炎肝硬化患者可提高治疗总有效率,改善T细胞亚群指标水平,降低中医证候积分、肝功能指标水平和肝纤维化指标水平,其效果优于单纯阿德福韦酯治疗。Objective:To observe effects of Biejiajian pills combined with Adefovir dipivoxil in treatment of patients with hepatitis B cirrhosis.Methods:A prospective study was conducted on 86 patients with hepatitis B cirrhosis admitted to the hospital from May 2020 to May 2023.According to the random number table method,they were divided into study group and control group,43 cases in each group.The control group was treated with Adefovir dipivoxil,while the study group was treated with Biejiajian pills on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores,the liver function indexes[total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)]levels,the liver fibrosis indexes[type IV collagen(C-IV),laminin(LN),hyaluronic acid(HA)]levels,the T cell subsets index levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.35%(41/43),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as abdominal fullness,anorexia and fatigue,andflank pain in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TBIL,ALT and AST in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of C-IV,LN and HA in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the++differences were statistically significant(P<0.05).After the treatment,the levels of CD3^(+) and CD4^(+) in the two groups were higher than those before+the treatment,and those in the study grou

关 键 词：鳖甲煎丸 阿德福韦酯 乙型肝炎肝硬化 肝纤维化 肝功能 T细胞亚群 不良反应 

分 类 号：R512.6[医药卫生—内科学]