药物涂层球囊与药物洗脱支架在下肢动脉硬化性闭塞症患者介入治疗中的效果比较  

Comparison of effects of drug-coated balloon and drug-eluting stent in interventional therapy for patients with lower extremity arteriosclerosis obliterans

作　　者：王瞻 WANG Zhan(Department of Interventional Radiography of Puyang Oilfield General Hospital,Puyang 4571000 Henan,China)

机构地区：[1]濮阳市油田总医院放射介入科,河南濮阳4571000

出　　处：《中国民康医学》2024年第16期148-151,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较药物涂层球囊(DCB)与药物洗脱支架在下肢动脉硬化性闭塞症(ASO)患者中的应用效果。方法:选取2020年8月至2022年8月该院收治的82例下肢ASO患者进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各41例。对照组采用雷帕霉素洗脱支架行经皮腔内血管成形术(PTA)治疗,研究组则采用DCB行PTA治疗。比较两组近期疗效,手术前后血管功能指标(靶动脉狭窄率和踝肱指数)水平,并发症发生率及术后1年靶动脉再狭窄、血运重建发生率。结果:研究组治疗总有效率为95.12%(39/41),对照组治疗总有效率为87.80%(36/41),组间比较差异无统计学意义(P>0.05);术后1个月,两组靶动脉狭窄率低于术前,踝肱指数大于术前,差异均有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);两组并发症发生率比较,差异无统计学意义(P>0.05);术后1年,研究组靶动脉再狭窄、血运重建发生率分别为14.63%、7.32%,低于对照组的53.66%、36.59%,差异均有统计学意义(P<0.05)。结论:DCB治疗下肢ASO患者的近期疗效、并发症发生率与药物洗脱支架相当,均能有效恢复血管内径和踝肱指数,但DCB可提高远期疗效,降低术后1年靶动脉再狭窄和血运重建发生率。Objective:To compare application effect of drug-coated balloon(DCB)and drug-eluting stent in patients with lower extremity arteriosclerosis obliterans(ASO).Methods:A prospective study was conducted on 82 patients with lower extremity ASO admitted to this hospital from August 2020 to August 2022.According to the random number table method,they were divided into study group and control group,41 cases in each group.Percutaneous transluminal angioplasty(PTA)was performed in both groups.The control group was treated with Rapamycin eluting stent,while the study group was treated with DCB.The short-term efficacy,the levels of vascular function indexes(target artery stenosis rate and ankle brachial index)before and after the surgery,the incidence of complications,the incidence of target artery restenosis,and the revascularization 1 year after the surgery were compared between the two groups.Results:The total effective rate of the study group was 95.12%(39/41),and that of the control group was 87.80%(36/41);there was no significant difference between the two groups(P>0.05).One month after the surgery,the target artery stenosis rates of the two groups were lower than those before the surgery,the ankle brachial index levels were higher than those before the surgery,and the differences were statistically significant(P<0.05);however,there were no significant differences between the two groups(P>0.05).One year after the surgery,the incidence of target artery restenosis and revascularization in the study group were 14.63%and 7.32%,respectively,which were lower than 53.66%and 36.59%in the control group,the differences were statistically significant(P<0.05).Conclusions:The short-term efficacy and the incidence of complications of DCB in the treatment of the patients with lower extremity ASO are comparable to those of drug-eluting stents.Both of them can effectively restore the inner diameter of blood vessels and the ankle brachial index,but DCB can improve the long-term efficacy and reduce the incidence of target artery restenosi

关 键 词：下肢 动脉硬化闭塞症 药物涂层球囊 药物洗脱支架 介入治疗 踝肱指数 

分 类 号：R654.4[医药卫生—外科学]