Cellular precision modulation of JAK1:tailoring therapies for allergic lung inflammation  

作　　者：Xiaocheng Yan Siegfried Ussar 

机构地区：[1]Research Unit Adipocytes&Metabolism(ADM),Helmholtz Diabetes Center,Helmholtz Zentrum München,German Research Center for Environmental Health GmbH,85764 Neuherberg,Germany [2]German Center for Diabetes Research(DZD),85764 Neuherberg,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第7期2843-2844,共2页信号转导与靶向治疗（英文）

基　　金：X.Y.received support from China Scholarship Council(No.201908370218).

摘　　要：In a recent publication published in Cell,Tamari et al.unraveled a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors show that sensory neuromodulation could be an important therapeutic avenue for the treatment of lung inflammation.It is now well established that the number of patients suffering from allergic disorders,like those suffering from obesity and the metabolic syndrome,is rapidly increasing world-wide,accelerating the burden on individual health and healthcare systems.Thus,basic and clinical researchers urgently need to develop novel therapeutics and approaches to limit or prevent disease development or progression.

关 键 词：JAK1 ALLERGIC LUNG 

分 类 号：R563[医药卫生—呼吸系统]