抗感合剂治疗流行性感冒急性高热期(热毒袭肺证)患者临床观察  

Clinical Efficacy Observation of Kanggan Mixture in Treating Patients with Acute High Fever Phase of Influenza(Syndrome of Heat-toxin Attacking Lung)

作　　者：程权 陆莉莉 石占利[3] 傅华洲[1] Cheng Quan;Lu Lili;Shi Zhanli;Fu Huazhou(Hangzhou First People′s Hospital,Zhejiang,Hangzhou 310006,China)

机构地区：[1]浙江省杭州市第一人民医院,浙江杭州310006 [2]浙江省杭州市拱墅区朝晖街道社区卫生服务中心,浙江杭州310014 [3]浙江省中西医结合医院,浙江杭州310006

出　　处：《中国中医急症》2024年第8期1432-1435,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号);浙江省自然科学基金项目(Y20H290003);浙江省医药卫生科技计划项目(2024KY1323);浙江省傅华洲名老中医专家传承工作室(GZS2020029)。

摘　　要：目的观察抗感合剂治疗流行性感冒急性高热期(热毒袭肺证)患者临床疗效。方法将204例患者按随机数字表法分观察组与对照组各102例,对照组予奥司他韦治疗,观察组予奥司他韦联合抗感合剂治疗。对比两组患者流感主要症状恢复率、体温改善情况、病毒核酸转阴率及实验室指标。结果观察组的流感主要症状在第5~7天的恢复率高于对照组(P<0.05)。观察组乏力、咳嗽、口渴、头痛、咽痛等5个单项流感症状恢复时间均短于对照组(P<0.01)。观察组的中位退热时间较对照组缩短7 h,组间差异具有统计学意义(P<0.05)。治疗第24和36小时观察组的退热比例显著高于对照组(P<0.05)。治疗后,观察组淋巴细胞比例(LY%)升高较对照组更为显著(P<0.05);治疗后,观察组C反应蛋白(CRP)和白细胞介素-6(IL-6)降低比例较对照组更为显著(P<0.05)。治疗后,观察组谷丙转氨酶(ALT)升高水平低于对照组(P<0.05);治疗后,观察组肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)改善情况明显优于对照组(P<0.05)。治疗过程中,在3 d和5 d两个时间点病毒核酸转阴率方面,观察组明显优于对照组(P<0.05)。结论抗感合剂联合治疗流行性感冒急性高热期(热毒袭肺证)患者疗效显著,效果优于单纯使用奥司他韦,联合应用可缩短流感病程和退热时间,调节血清炎症指标,改善心肌酶降低病毒性心肌炎风险,且具有良好的安全性。Objective:To observe the clinical efficacy of Kanggan Mixture in treating patients with influenza during the acute high fever phase(syndrome of heat-toxin attacking lung).Methods:A total of 204 patients were divided into an observation group and a control group of 102 cases each using the random number table method.The control group received oseltamivir treatment,while the observation group received a combination of oseltamivir and Kanggan Mixture.The recovery rates of main influenza symptoms,improvement of body temperature,viral nucleic acid negative conversion rate,and laboratory indicators were compared between the two groups.Results:The recovery rate of main influenza symptoms in the observation group on days 5 to 7 was higher than that in the control group(P<0.05).The time for recovery of five individual influenza symptoms including fatigue,cough,thirst,headache,and sore throat was shorter in the observation group compared with the control group(P<0.01).The median time to defervescence in the observation group was 7 hours shorter than in the control group,with a statistically significant difference(P<0.05).The proportion of patients who had a fever reduction at 24 and 36 hours was significantly higher in the observation group than in the control group(P<0.05).After treatment,the increase in lymphocyte percentage(LY%)in the observation group was more significant than in the control group(P<0.05);after treatment,the decrease in C-reactive protein(CRP)and interleukin-6(IL-6)levels in the observation group was more significant than in the control group(P<0.05).After treatment,the level of alanine aminotransferase(ALT)elevation in the observation group was lower than in the control group(P<0.05);after treatment,the improvement in creatine kinase(CK)and CK-MB in the observation group was significantly better than in the control group(P<0.05).During the course of treatment,at the 3 day and 5 day time points,the viral nucleic acid negative conversion rate was significantly better in the observation group compared to

关 键 词：流行性感冒 急性高热期 抗感合剂 热毒袭肺 临床疗效 

分 类 号：R511.7[医药卫生—内科学]