肠风饮内服灌肠治疗宫颈癌放疗后急性放射性直肠炎临床观察  

Clinical Study on Changfeng Decoction Internal Drink and Enema for Acute Radiation Proctitis after Cervical Cancer Radiotherapy

作　　者：单强 刘瑞梅 祁小非 Shan Qiang;Liu Ruimei;Qi Xiaofei(Binzhou Traditional Chinese Medicine Hospital,Binzhou,Shandong 256613,China)

机构地区：[1]山东省滨州市中医医院,山东滨州256613

出　　处：《中国中医急症》2024年第8期1440-1442,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2019-498)。

摘　　要：目的观察肠风饮内服灌肠治疗宫颈癌放疗后急性放射性直肠炎(ARP)临床疗效。方法将宫颈癌放疗后ARP患者90例随机分为两组各45例,对照组给予西药灌肠治疗,观察组给予肠风饮内服灌肠治疗;比较两组临床疗效、治疗前后中医证候评分、直肠黏膜评分、Karnofsky功能状态评分、炎症因子指标及不良反应发生情况。结果观察组治疗总有效率为93.33%,明显高于对照组的73.33%(P<0.05),治疗后中医证候评分、直肠黏膜评分、炎症因子水平及Karnofsky功能状态评分较对照组明显改善(P<0.05)。结论肠风饮内服灌肠治疗宫颈癌放疗后ARP可有效控制病情,改善生活质量,并有助于抑制炎症细胞因子表达。Objective:To observe the clinical efficacy of Changfeng Decoction enema in treating acute radiation proctitis(ARP)after cervical cancer radiotherapy.Methods:Ninety ARP patients after cervical cancer radiotherapy were randomly allocated into a control group(45 cases)receiving western medicine enemas and an observation group(45 cases)receiving Changfeng Decoction internal drink and enema.Clinical efficacy,pre-and post-treatment scores of TCM syndromes,rectal mucosa condition,Karnofsky performance status(KPS)scores,levels of inflammatory factors,and incidence of adverse reactions were compared between the two groups.Results:The overall effective rate in the observation group was 93.33%,which was significantly higher than 73.33%in the control group(P<0.05).After treatment,the observation group demonstrated significantly improved TCM syndrome scores,rectal mucosa scores,inflammatory factor levels,and KPS scores compared with the control group(P<0.05).Conclusion:Internal drink and enema of Changfeng Decoction enhances quality of life and contributes to suppressing the expression of inflammatory cytokines.

关 键 词：急性放射性直肠炎 宫颈癌 肠风饮 放疗 

分 类 号：R516.1[医药卫生—内科学]