基于中药引经理论的靶向制剂设计基础思考与实践  

Practice and contemplation in target drug delivery design based on the meridian guide theory of traditional Chinese medicine

作　　者：赵瑞芝 赵亚 刘丽娟 吴亚运 ZHAO Rui-zhi;ZHAO Ya;LIU Li-juan;WU Ya-yun(State Key Laboratory of Chinese Medicine for Dampness Syndrome,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510006;Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome,Guangzhou 510120)

机构地区：[1]广州中医药大学第二附属医院省部共建中医湿证重点实验室,广州510006 [2]广东省中医证候临床研究重点实验室,广州510120

出　　处：《中南药学》2024年第7期1801-1806,共6页Central South Pharmacy

基　　金：国家自然科学基金项目(No.81573612,No.82173981,No.81073063)。

摘　　要：本文通过回顾引经靶向思想的提出以及利用现代药物动力学、分子生物学等多学科技术方法进行设想验证的过程及结果,指出利用现代科学技术有望阐明中药药性理论的科学内涵,并据此推进临床合理用药、新剂型研制、功能辅料开发等的发展。By reviewing the concept of target drug delivery based on median-guide theory and its validation process by pharmacokinetics and molecular biology,this paper indicated that the scientific connotations of Chinese medicine could be explained by modern technology,which may facilitate the development of drug use,new delivery methods as well as development of function excipients.

关 键 词：引经药 组织差异 靶向 

分 类 号：R283[医药卫生—中药学]