托法替布片药物利用评价标准建立及应用  

Establishment of drug use evaluation criteria for tofacitinib tablets and application

作　　者：曹迪[1] 程军[1] 张士洋[1] 司福国 CAO Di;CHENG Jun;ZHANG Shi-yang;SI Fu-guo(Department of Pharmacy,the Third People’s Hospital of Bengbu,Bengbu Anhui 233000)

机构地区：[1]蚌埠市第三人民医院药学部,安徽蚌埠233000

出　　处：《中南药学》2024年第7期1909-1914,共6页Central South Pharmacy

摘　　要：目的建立托法替布片药物利用评价标准(DUE),为托法替布片临床合理使用提供参考。方法参考国内外托法替布药品说明书、相关诊疗指南、专家共识及临床研究,建立托法替布片DUE标准,并以此标准回顾性分析某三甲医院2021年1月1日—2023年9月30日托法替布片门诊处方的合理性。结果共纳入1086张托法替布片门诊处方,用药适应证符合率93.6%,用法用量符合率93.6%,4张处方存在潜在的药物相互作用。结论该院托法替布片使用较合理,但在适应证、用法用量、药物相互等方面仍存在一定的问题,应加强干预,确保患者用药安全。Objective To establish the drug use evaluation(DUE)standard for tofacitinib tablets and provide a reference for the rationally clinical use of tofacitinib tablets.Methods Based on tofacitinib drug label,expert consensus on related guidelines and clinical research,DUE criteria for tofacitinib tablet were developed.The outpatient and emergency prescriptions of tofacitinib tablets from January 1,2021 to September 30,2023 in a GradeⅢHospital were retrospectively analyzed.Results Totallly 1086 prescriptions were included,the compliance rate of medication indications was 93.6%,and the compliance rate of usage and dosage reached 93.6%.Potential drug-drug interactions were found in 4 prescriptions.Conclusion The use of tofacitinib tablets in the hospital is fairly reasonable.Problems exist in indications,usage and dosage,and drug interactions.Intervention should be strengthened to ensure the safety of patient medication.

关 键 词：托法替布片 药物利用评价 合理用药 评价标准 

分 类 号：R969.3[医药卫生—药理学]