地佐辛、喷他佐辛用于胃癌根治术患者术后镇痛的药物经济学评价  

Pharmacoeconomic evaluation of postoperative analgesia in patients undergoing radical gastrectomy with dezocine or pentazocine

作　　者：吴廷庆 肖洋 牛露露 蔡荣达 吴冬妮 刘滔滔[1] WU Ting-qing;XIAO Yang;NIU Lu-lu;CAI Rong-da;WU Dong-ni;LIU Tao-tao(Department of Pharmacy,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021;Guangxi Hospital Division of the First Affiliated Hospital,Sun Yat-Sen University,Nanning 530028)

机构地区：[1]广西医科大学第一附属医院药学部,南宁530021 [2]中山大学附属第一医院广西医院,南宁530028

出　　处：《中南药学》2024年第7期1924-1928,共5页Central South Pharmacy

摘　　要：目的探讨两种胃癌术后镇痛方案的药物经济学评价。方法回顾性分析2020年10月—2022年9月在某院胃癌根治手术患者162例,按术后镇痛用药的不同分为A组和B组,A组给予地佐辛注射液(76例),B组给予喷他佐辛注射液(86例),统计两组患者的镇痛效果、不良反应、成本等,运用成本-效果分析法进行分析评价。结果安全性方面,A组不良反应发生率为2.63%,B组不良反应发生率为4.65%,差异无统计学意义;疗效方面,各时间段A组疼痛数字评分(NRS)均显著小于B组(P<0.05);A组累计有效率为96.09%,B组累计有效率为70.55%,差异有统计学意义(P<0.05)。药物经济学方面,A组总成本为(969.82±250.76)元,B组总成本为(795.62±108.23)元,A组成本-效果比(C/E)为1010.23,B组C/E为1120.59,增量成本效果比为696.80元,敏感性分析支持成本效果分析。结论胃癌术后镇痛中地佐辛注射液相对于喷他佐辛注射液具有经济学优势。Objective To evaluate the pharmacoeconomics of two postoperative analgesia schemes commonly used in radical surgery for gastric cancer.Methods Totally 162 patients with gastric cancer undergoing radical surgery were retrospectively analyzed in a hospital from October 2020 to September 2022.According to the analgesic drugs used,patients were divided into group A and group B.Group A were injected dezocine(76 patients),and group B were injected pentazocine(86 patients).The analgesic effects,adverse reactions and costs of the two groups were analyzed by the cost-effectiveness analysis.Results In terms of safety,the incidence of adverse reactions of group A was 2.63%,and that of group B was 4.65%,with no significant difference(P>0.05).As to curative effect,the numerical rating scale of group A was lower than that of group B at each time period(P<0.05).The cumulative effective rates in group A and group B were 96.09%and 70.55%,respectively(P<0.05).In terms of pharmacoeconomics,the total cost of group A was(969.82±250.76)yuan,and that of group B was(795.62±108.23)yuan.The cost-effectiveness ratio(C/E)was 1010.23 for group A,and 1120.59 for group B,and the incremental cost-effectiveness ratio was 696.80 yuan.The sensitivity analysis supported the cost-effectiveness analysis.Conclusion Dezocine injection has economic advantages over pentazocine injection in postoperative analgesia for gastric cancer.

关 键 词：地佐辛 喷他佐辛 胃癌术后镇痛 镇痛效果 药物经济学 成本效果分析 

分 类 号：R956[医药卫生—药学]