1例暴发性心肌炎行体外膜肺氧合联合连续肾脏替代治疗继发动脉血栓患儿个体化抗栓治疗分析  

Individualized antithrombotic therapy for a child suffering from fulminant myocarditis with arterial thrombosis secondary to extracorporeal membrane oxygenation combined with continuous renal replacement therapy

作　　者：高年婷 王欣怡 李波霞[3] GAO Nian-ting;WANG Xin-yi;LI Bo-xia(Department of Pharmacy,Qinghai Traffic Hospital,Xining 810000;The First Clinical Medical College of Lanzhou University,Lanzhou 730000;Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000)

机构地区：[1]青海省交通医院药剂科,西宁810000 [2]兰州大学第一临床医学院,兰州730000 [3]兰州大学第一医院药剂科,兰州730000

出　　处：《中南药学》2024年第7期1953-1956,共4页Central South Pharmacy

基　　金：甘肃省科技计划项目(No.21JR7RA380)。

摘　　要：本文报道了1例暴发性心肌炎儿童患者经体外膜肺氧合(ECMO)联合连续肾脏替代治疗(CRRT)后继发导管相关性下肢动脉血栓,临床药师通过查阅文献及循证证据,结合动脉血栓特点制订个体化的抗栓治疗方案,并进行药学监护,最终患儿转归良好。患儿ECMO抗凝治疗仍缺少大规模研究,目前为止尚缺少权威性指南。临床药师应熟练掌握抗栓药物特点,结合患者个体情况权衡风险和获益,协助医师制订个体化治疗方案,提高临床药物治疗的有效性和安全性。This article reported a case of catheter-related lower extremity arterial thrombosis in a child suffering from fulminant myocarditis treated with extracorporeal membrane oxygenation(ECMO)and continuous renal replacement therapy(CRRT).Clinical pharmacists developed individualized antithrombotic therapy based on literatures and evidences,and conducted pharmaceutical monitoring.The child had a good outcome.There is not enough lack of large-scale studies on anticoagulation therapy with ECMO in children,and lacks authoritative guidelines.Clinical pharmacists should be familiar with the characteristics of antithrombotic drugs,assist physicians to establish individualized treatment plans,and improve the effectiveness and safety of clinical drugs.

关 键 词：暴发性心肌炎 体外膜肺氧合 连续肾脏替代治疗 下肢动脉血栓形成 抗血栓治疗 

分 类 号：R542.21[医药卫生—心血管疾病]