首次辅助生殖女性患者抑郁焦虑情绪与家庭功能、病耻感关系及对助孕结局的影响  

Correlation between the depression and anxiety of patients with the first assisted reproductive technology and their family function and stigma and its influence on the outcomes of assisted reproduction

作　　者：蔡杨 何玉萍 康旭丽 赵丽敏 高珊 CAI Yang;HE Yuping;KANG Xuli;ZHAO Limin;GAO Shan(Air Force Medical University Second Afiliated Hospital,Xian,Shanxi Province,710038)

机构地区：[1]空军军医大学第二附属医院,西安710038

出　　处：《中国计划生育学杂志》2024年第8期1734-1739,共6页Chinese Journal of Family Planning

摘　　要：目的:探讨首次辅助生殖患者抑郁焦虑情绪状况及与家庭功能、病耻感关系及对助孕结局的影响。方法:选择2022年10月-2023年10月在本院首次接受辅助生殖助孕的女性患者162例,于进入治疗周期第1天采用一般资料调查表、抑郁自评量表(SDS)、焦虑自评量表(SAS)、家庭关怀度指数问卷(APGAR)、不孕症患者羞辱感量表(ISS)调查患者基线资料、焦虑、抑郁、家庭功能、病耻感情况,比较有无抑郁焦虑症状患者基线资料、家庭功能、病耻感差异,logistic回归分析模型调整混杂因素后分析家庭功能、病耻感与患者抑郁焦虑症状关系。观察抑郁焦虑症状与助孕结局。结果:本次共发放162份问卷,回收152份有效问卷,有效率93.8%。APGAR评分7.68±0.82分,ISS评分70.44±16.13分。SDS评分43.71±8.53分,抑郁检出率为30.9%;SAS评分47.94±9.05分,焦虑检出率为38.8%。年龄、居住地、文化程度、不孕年限、流产史、APGAR、ISS评分与助孕患者抑郁症状有关,居住地、家庭月收入、不孕年限、流产史、APGAR、ISS评分与助孕患者焦虑有关(均P<0.05)。经分析APGAR与ISS评分之间存在显著共线性,故将两者分别引入多因素logistic回归模型中,调整了抑郁、焦虑混杂影响因素后显示,高APGAR评分为助孕患者抑郁、焦虑的独立保护因素(OR=0.405、0.427),高ISS评分为独立危险因素(OR=1.299、1.271),存在抑郁焦虑症状患者助孕临床妊娠率(48.9%、45.8%)低于无抑郁焦虑患者(67.6%、72.0%)(均P<0.05)。结论:首次辅助生殖患者易出现抑郁焦虑症状,可对助孕结局造成不良影响,通过系统家庭及心理干预可能是改善患者抑郁焦虑状况的潜在途径。Objective:To explore the correlation between the depression and anxiety of patients with the first assisted reproductive technology and their family function and stigma,and to study its influence on the outcomes of assisted reproduction.Methods:A total of 162 patients who received assisted reproductive technology for the first time in the hospital from October 2022 to October 2023 were selected in this study.On the first day of the treatment cycle,the general data questionnaire,the self-rating depression scale(SDS),the self-rating anxiety scale(SAS),the family APGAR index(APGAR)and the infertility stigma scale(ISS)were used to investigate the baseline data,the situation of anxiety and depression,the family function and the stigma of these patients.The differences of the baseline data,the family function and the stigma were compared between the patients with and without depression and anxiety symptoms.The correlation between the family function and stigma of the patients with the first assisted reproductive technology and their depression and anxiety symptoms after adjusting confounding factors was analyzed by logistic regression analysis model.The depression and anxiety symptoms of the patients with assisted reproduction were observed,Results:A total of 162 questionnaires were delivered,and 152 effective questionnaires were returned,and with the effective rate of 93.8%.The scores of APGAR,ISS,SDS and SAS of these patients were 7.68±0.82 points,70.44±16.13 points,43.71±8.53 points and 47.94±9.05 points,respectively.The detection rates of depression and anxiety of these patients were 30.9%and 38.8%.The age,the place of residence,the education level,the duration of infertility,the abortion history,the APGAR and ISS scores of the patients with the first assisted reproductive technology were correlation with their depressive symptoms.And the place of residence,the family income,the duration of infertility,the abortion history,the APGAR and ISS scores of the patients with the first assisted reproductive technology

关 键 词：辅助生殖 抑郁焦虑 家庭功能 病耻感 助孕结局 

分 类 号：R714.8[医药卫生—妇产科学]