宫瘤消胶囊治疗异常子宫出血疗效  

Efficacy of Gongliuxiao capsule for treating patients with abnormal uterine bleeding

作　　者：张玲玲 黄玉红 万超 许萍 ZHANG Lingling;HUANG Yuhong;WAN Chao;XU Ping(Xuancheng City Central Hospital,Xuancheng,Anhui Province,242000;The First Affiliated Hospital of Anhui Chinese Medical University,Hefei)

机构地区：[1]安徽省宣城市中心医院,242000 [2]安徽中医药大学第一附属医院

出　　处：《中国计划生育学杂志》2024年第8期1819-1822,1827,共5页Chinese Journal of Family Planning

摘　　要：目的:探究宫瘤消胶囊治疗异常子宫出血(AUB)疗效及对患者血红蛋白(Hb)、性激素、凝血功能指标的影响。方法:选取2021年1月-2023年9月就诊于本院的AUB患者82例,数字表法随机分为联合组和对照组各41例。两组均给予地屈孕酮片治疗,联合组加用宫瘤消胶囊治疗,两组均治疗3个月后对比临床疗效及安全性,监测用药前后血Hb、性激素水平、子宫内膜厚度及凝血功能指标变化。结果:治疗后,联合组治疗总有效率(92.7%)高于对照组(75.6%),Hb水平(126.93±16.53 g/L)高于对照组(101.16±13.46 g/L),促黄体生成素(35.12±5.64 U/L)、雌二醇(185.73±11.26 U/L)、卵泡刺激素(24.86±4.59 U/L)、活化部分凝血活酶时间(24.68±1.09s)、凝血酶原时间(12.26±0.13s)、凝血酶时间(15.03±0.27s)、纤维蛋白原(2.65±0.24g/L)水平及子宫内膜厚度(6.67±1.24mm)均低于对照组(43.56±3.82U/L、248.53±9.36U/L、32.37±5.14U/L、29.74±2.36s、13.27±0.39s、17.39±0.86s、3.49±0.43 g/L、9.37±2.01mm),不良反应发生率(7.3%)低于对照组(24.4%)(均P<0.05)。结论:地屈孕酮片联合宫瘤消胶囊用于AUB临床治疗疗效提高,能够有效促进Hb、性激素水平与子宫内膜厚度恢复正常并改善凝血功能。Objective:To explore the efficacy and safety of Gongliuxiao capsule for treating patients with abnormal uterine bleeding(AUB),and to study its influence on the levels of the hemoglobin(HGB),sex hormones and coagulation function indexes of the patients.Methods:82 patients with AUB were selected and were divided into the study group and control group(41 cases in each group)by random number table from January 2021 to September 2023.The patients in the two groups were given treatment of dydrogesterone tablet,and the patients in the study group were given Gongliuxiao capsule additionally.The clinical efficacy and the safety of the patients after 3 months of treatment were compared between the two groups.The changes of the levels of HGB and sex hormones levels,the endometrial thickness and the coagulation function indexes levels of the patients in the two groups before and after treatment were monitored.Results:The total effective rate(92.7%)and the Hb level(126.93±16.53 g/L)of the patients in the study group after treatment were significantly higher than those(75.6%and 101.16±13.46 g/L)of the patients in the control group.The levels of luteinizing hormone(35.12±5.64 U/L),estradiol(185.73±11.26 U/L)and follicle stimulating hormone(24.86±4.59 U/L),and the values of activated partial thromboplastin time(24.68±1.09 s),prothrombin time(12.26±0.13 s)and thrombin time(15.03±0.27 s),the fibrinogen level(2.65±0.24 g/L)and the endometrial thickness(6.67±1.24 mm)of the patients in the study group after treatment were significantly lower than those(43.56±3.82 U/L,248.53±9.36 U/L,32.37±5.14 U/L,29.74±2.36 s,13.27±0.39 s,17.39±0.86 s,3.49±0.43 g/L and 9.37±2.01mm)of the patients in the control group.The incidence of the adverse reactions(7.3%)of the patients in the study group was significantly lower than that(24.4%)of the patients in the control group(all P<0.05).Conclusion:The dydrogesterone tablet combined with Gongliuxiao capsule for treating the patients with AUB can improve the efficacy,which can effectively

关 键 词：异常子宫出血 宫瘤消胶囊 地屈孕酮片 血红蛋白 子宫内膜厚度 凝血功能 性激素 临床疗效 不良反应 

分 类 号：R271.9[医药卫生—中西医结合]