滋阴补阳方序贯法联合西药治疗PCOS效果及对卵巢储备功能影响  

Effect of Ziyinbuyang sequential method combined with western medicine for treating patients with polycystic ovary syndrome and its influence on the ovarian reserve function of the patients

作　　者：杨冬梅 范敏舟 吴菲菲 YANG Dongmei;FAN Minzhou;WU Feifei(Wuhu Chinese and Western Medicine Hospital(Wanzhi District General Hospital),Wuhu,Anhui Province,241100)

机构地区：[1]安徽省芜湖市中西医结合医院(湾沚区总医院),241100

出　　处：《中国计划生育学杂志》2024年第8期1823-1827,共5页Chinese Journal of Family Planning

摘　　要：目的:探究滋阴补阳方序贯法联合西药治疗多囊卵巢综合征(PCOS)效果及对卵巢储备功能的影响。方法:选取2021年8月-2022年10月本院收治的PCOS患者126例,简单随机(抽签法)分为西药组和中西联合组各63例,两组均采取西药治疗,中西联合组联合滋阴补阳方序贯法治疗。比较两组临床疗效,中医症状积分、卵巢储备指标、卵巢及卵泡指标变化及不良反应,持续随访1年,记录排卵及妊娠情况。结果:治疗后,中西联合组总有效率(93.7%)高于西药组(81.0%),两组中医症状各积分均降低且中西联合组低于西药组,两组卵泡刺激素、黄体生成素/卵泡刺激素、抑制素B、抗苗勒管激素均降低且中西联合组低于西药组,两组卵巢体积、AFC均下降且中西联合组(5.18±0.84mm、8.63±1.27个)低于西药组(5.83±0.57mm、10.45±1.82个)(均P<0.05)。治疗期间不良反应发生率中西联合组(4.8%)与西药组(1.6%)无差异(P=0.310);随访1年内,中西联合组排卵率(88.9%)和妊娠率(39.7%)均高于西药组(71.4%、22.2%)(均P<0.05)。结论:滋阴补阳方序贯法结合西药治疗PCOS提高了患者临床症状和卵巢储备功能改善程度,提高了治疗后排卵和妊娠率,用药安全性良好。Objective:To explore the effect of Ziyinbuyang sequential method combined with western medicine for treating patients with polycystic ovary syndrome(PCOS),and to study its influence on the ovarian reserve function of the patients.Methods:126 patients with PCOS were selected and were divided into control group(63 cases)and study group(63 cases)by simple randomization(lottery method)from August 2021 to October 2022.The patients in the control group were treated with western medicine therapy,while the patients in the study group were given Ziyinbuyang sequential method combined with western medicine therapy.The clinical efficacy,the traditional Chinese medicine(TCM)symptoms scores,the indicators of ovarian reserve,ovarian and follicular change,and the adverse reactions rate of the patients were compared between the two groups.The patients in the two groups were followed up for 1year,and the ovulation and the pregnancy status of the patients in the two groups were recorded.Results:The total effective rate(93.7%)of the patients in the study group after treatment was significantly higher than that(81.0%)of the patients in the control group.The TCM symptom scores of the patients in the two groups after treatment had decreased significantly,and which of the patients in the study group were significantly lower than those of the patients in the control group.The levels of follicle-stimulating hormone,inhibin B and anti-Mullerian hormone,and the value of luteinizing hormone/follicle-stimulating hormone of the patients in the two groups after treatment had decreased significantly,and which of the patients in the study group were significantly lower than those of the patients in the control group.The values of ovarian volume and AFC of the patients in both groups after treatment had decreased significantly,and which(5.18±0.84mm and 8.63±1.27)of the patients in the study group were significantly lower than those(5.83±0.57mm and 10.45±1.82)of the patients in the control group(all P<0.05).There was no significant difference

关 键 词：多囊卵巢综合征 滋阴补阳方序贯法 西药 卵巢储备功能 卵巢体积 排卵 妊娠 

分 类 号：R711.75[医药卫生—妇产科学]