先兆流产患者保胎结局影响因素及与血清sHLA-G、ACA水平关系  

Factors influencing the fetal protection outcomes of pregnant women with threatened abortion and their correlation with the levels of serum soluble human leukocyte antigen-G and anticardiolipin antibody

作　　者：凌艳娟 王芳[1] 涂春燕 邹婷 LING Yanjuan;WANG Fang;TU Chunyan;ZOU Ting(Ziyang Hospital,West China Hospital of Sichuan University,Ziyang Central Hospital,Ziyang,Sichuan Prou-ince,641300;Chengdu J inxin Re productive Medicine and Genettics Institute,Chengdu)

机构地区：[1]四川大学华西医院资阳医院,资阳市中心医院,641300 [2]成都锦欣生殖医学与遗传学研究所

出　　处：《中国计划生育学杂志》2024年第8期1883-1887,共5页Chinese Journal of Family Planning

基　　金：2020年四川省青年创新科研课题(Q20055)。

摘　　要：目的:探索先兆流产患者保胎结局的影响因素,并分析其与血清可溶性人白细胞抗原-G(sHLA-G)、抗心磷脂抗体(ACA)的关系。方法:回顾性收集2021年6月-2023年6月本院收治的80例先兆流产患者临床资料,根据保胎结局分为保胎失败组与保胎成功组,对比两组一般资料,酶联免疫吸附法检测两组sHLA-G、ACA水平,经单因素及Pearson相关性分析法探讨先兆流产保胎结局的影响因素及与血清sHLA-G、ACA水平关系。结果:两组年龄、既往流产史、合并阴道炎、生殖道感染、妊娠期糖尿病、接触有毒化学物质等方面有差异;保胎失败组sHLA-G(7.43±1.20 U/ml)水平低于保胎成功组(50.14±4.56 U/ml),ACA阳性率(74.1%)高于保胎成功组(20.8%)(均P<0.05)。logistic回归分析,高龄、既往流产史、合并阴道炎、生殖道感染、妊娠期糖尿病、接触有毒化学物质、sHLA-G水平低、ACA阳性率高均是影响先兆流产患者保胎结局的重要因素;Pearson相关性分析,年龄、既往流产史、合并阴道炎、生殖道感染、妊娠期糖尿病、接触有毒化学物质与血清sHLA-G水平呈负相关,与ACA阳性率呈正相关(均P<0.05)。结论:先兆流产患者保胎结局可能与高龄、既往流产史、合并阴道炎、生殖道感染、妊娠期糖尿病、接触有毒化学物质、sHLA-G水平及ACA阳性率有关,临床可针对上述因素给予密切关注,并通过监测sHLA-G水平及ACA阳性率的变化来指导临床早期干预,以确保母婴安全。Objective:To explore the factors influencing fetal protection outcomes of pregnant women with threatened abortion,and to analyze their correlation with the levels of serum soluble human leukocyte antigen-G(sHLA-G)and anticardiolipin antibody(ACA)of the women.Methods:The clinical data of 80 pregnant women with threatened abortion who admitted to the hospital from June 2021 to June 2023 were collected retrospectively.These women were divided into group A(women with the failed fetal protection)and group B(women with the successful fetal protection)according to the outcome of their fetal protection.The general information of the women was compared between the two groups.The levels of sHLA-G and ACA of the women in the two groups were detected by enzyme-linked immunosorbent assay.Single factor analysis and Pearson correlation analysis method were used to analyze the influencing factors of the fetal protection outcomes of the women with threatened abortion and the correlation between the fetal protection outcomes of the women with threatened abortion and their serum sHLA-G and ACA levels.Results:There were significant differences in the age,the history of abortion,the complicated with vaginitis,the gestational diabetes mellitus,and the situation of exposure to the toxic chemicals of the women between the two groups.The level of sHLA-G(7.43±1.20 U/ml)of the women in group A was significantly lower than that(50.14±4.56 U/ml)of the women in group B,and the positive rate(74.1%)of ACA of the women in group A was significantly higher than that(20.8%)of the women in group B(all P<0.05).Logistic regression analysis showed that the advanced age,the previous abortion history,the complicated with vaginitis,the gestational diabetes mellitus,the situation of exposure to the toxic chemicals,the low sHLA-G level and the high positive rate of ACA of the women with threatened abortion were the important factors affecting their fetal protection outcomes.Pearson correlation analysis showed that the age,the history of abortion,the compl

关 键 词：先兆流产 保胎结局 血清可溶性人白细胞抗原-G 抗心磷脂抗体 影响因素 

分 类 号：R714.21[医药卫生—妇产科学]