GDM患者血清CTRP3、FGF19水平与不良妊娠结局关系  

Correlation between the serum CTRP3 and FGF19 levels of pregnant women with gestational diabetes mellitus and their adverse pregnancy outcomes

作　　者：万红梅 马红梅 谷文文 WAN Hongmei;MA Hongmei;GU Wenwen(Maanshan People's Hospital,Maanshan,Anhui Province,243000)

机构地区：[1]安徽省马鞍山市人民医院,243000

出　　处：《中国计划生育学杂志》2024年第8期1898-1902,共5页Chinese Journal of Family Planning

基　　金：马鞍山市健康委员会(MASWJ2023c003)。

摘　　要：目的:探讨妊娠期糖尿病(GDM)患者血清补体C1q/肿瘤坏死因子相关蛋白3(CTRP3)、成纤维细胞因子19(FGF-19)水平与不良妊娠结局的关系及预测价值。方法:回顾性纳入2020年1月-2023年12月本院就诊的GDM患者104例(GDM组),按是否发生不良妊娠结局分为结局不良组(n=38)与结局良好组(n=76);另选取健康孕妇100例为对照组。均完成孕晚期血清CTRP3、FGF19水平检测,分析血清CTRP3、FGF19与GDM不良妊娠结局关系,使用受试者工作特征(ROC)曲线评价二项指标不良妊娠结局价值。结果:GDM组血清CTRP3(0.54±0.16μg/L)、FGF19(55.48±15.61 pg/ml)水平低于对照组(0.66±0.19μg/L、64.89±17.23 pg/ml),妊娠结局不良组CTRP3、FGF19水平低于结局良好组(均P<0.05)。logistic回归分析,血清CTRP3、FGF19水平降低是GDM患者不良妊娠结局危险因素(P<0.05)。ROC曲线分析,血清CTRP3、FGF19水平预测GDM患者不良妊娠结局曲线下面积分别为0.710、0.724,二者联合检测的曲线下面积0.789。结论:GDM患者血清CTRP3、FGF19水平降低,且是患者发生不良妊娠结局的危险因素,二项指标均对不良妊娠结局有预测价值,且联合应用可提高预测效能。Objective:To investigate the correlation between the complement Clq/tumor necrosis factor-related protein3(CTRP3),fibroblast growth factor 19(FGF-19)of pregnant women with gestational diabetes mellitus(GDM)and their adverse pregnancy outcomes,and to study the predictive values of the serum CTRP3 and FGF19 levels of the women for their adverse pregnancy outcomes.Methods:A total of 114 pregnant women with GDM from January 2020to December 2023 were included in study group retrospectively.According to whether the adverse pregnancy outcomes occurred,these women were divided into group A(38 women with adverse pregnancy outcomes)and group B(76women with normal pregnancy outcomes).Another 100 healthy pregnant women during the same period were selected in control group.All the women in these groups had completed the detections of the serum CTRP3 and FGF19 levels during the third trimester of pregnancy.The correlation between the serum CTRP3 and FGF19 levels of the women with GDM and their adverse pregnancy outcomes was analyzed.Receiver operating characteristic(ROC)curve was used to evaluate the serum CTRP3 and FGF19 levels of the women with GDM for predicting their adverse pregnancy outcomes.Results:The levels of serum CTRP3(0.54±0.16μg/L)and FGF19(55.48±15.61 pg/ml)of the women in the study group were significantly lower than those(0.66±0.19μg/L and 64.89±17.23 pg/ml)of the women in the control group.The CTRP3 and FGF19 levels of the women in group A were significantly lower than those of the women in group B(all P<0.05).Logistic regression analysis showed that the decreased serum CTRP3 and FGF19 levels of the women with GDM were the risk factors of their adverse pregnancy outcomes(P<0.05).ROC curve analysis showed that the area under curve of the serum levels of CTRP3 and FGF19 of the women with GDM for predicting their adverse pregnancy outcomes were 0.710,0.724,and the area under the curve of the combined levels of CTRP3 and FGF19 of the women with GDM for predicting their adverse pregnancy outcomes was 0.789.C

关 键 词：妊娠期糖尿病 补体C1q/肿瘤坏死因子相关蛋白3 成纤维细胞因子19 不良妊娠结局 危险因素 预测 

分 类 号：R714.256[医药卫生—妇产科学]