Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond  

作　　者：Guiya Yang Yue Liu Yuying Hu Yue Yuan Yunan Qin Quan Li Shuangcheng Ma 

机构地区：[1]School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing,102488,China [2]Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing,100050,China [3]Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine,School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China [4]Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry,Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules,College of Chemistry and Chemical Engineering,Hubei University,Wuhan,430062,China

出　　处：《Journal of Pharmaceutical Analysis》2024年第6期823-839,共17页药物分析学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.:82374033,21901067);Ministry of Science and Technology of China(Grant No.:2023YFC3504100);Starting Grant from the Ministry of Human Resource and Social Security of China(Quan Li).

摘　　要：Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

关 键 词：Electron microscopy SPECTROSCOPY Traditional Chinese medicine Bio-soft matter Structural characterization 

分 类 号：R284[医药卫生—中药学]