Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside  

作　　者：Shiyu Chen Yuxuan Li Yingrui Zhang Hongren Yao Tong Xu Yi Zhang Jin-Ming Lin Xian-Li Meng 

机构地区：[1]State Key Laboratory of Southwestern Chinese Medicine Resources,Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China [2]Beijing Key Laboratory of Microanalytical Methods and Instrumentation,Department of Chemistry,Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education),Tsinghua University,Beijing,100084,China [3]School of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China

出　　处：《Journal of Pharmaceutical Analysis》2024年第6期926-929,共4页药物分析学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.:82274207,81973569,22034005);the Xinglin Scholar Research Promotion Project of Chengdu University of Traditional Chinese Medicine,China(Grant No.:XKTD2022013);the Sichuan Provincial Natural Science Foundation,China(Grant No.:24NSFSC1748).

摘　　要：Microneurovascular units(mNVUs),comprising neurons,micro-glia,and blood-brain barrier(BBB)endothelial cells,are pivotal to the central nervous system and are associated with cerebral hypoxia and brain injuries.Cerebral hypoxia triggers microglial overactivity,causing inflammation,neuronal injury,and disruption of the BBB[1].Salidroside(Sal),a key compound in Tibetan medicine Rhodiola crenulata,mitigates hypoxia-induced metabolic disorders and neuronal damage by preserving mitochondrial function[2].

关 键 词：injuries preserving TIBETAN 

分 类 号：R283.6[医药卫生—中药学]