An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke  

作　　者：Junfeng Wang Qibing Liu Yingbo Li Yi Pang 

机构地区：[1]Department of Chemistry,The University of Akron,Akron,OH 44325,USA [2]Gordon Center for Medical Imaging,Department of Radiology,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,USA [3]Department of Pharmacy,The First Affiliated Hospital of Hainan Medical University,Haikou,570100,China [4]Engineering Research Center of Tropical Medicine,Ministry of Education,Hainan Medical University,Haikou,571199,China [5]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,100191,China [6]Maurice Morton Institute of Polymer Science,The University of Akron,Akron,OH 44325,USA

出　　处：《Journal of Pharmaceutical Analysis》2024年第4期578-584,共7页药物分析学报（英文版）

基　　金：supported by the National Institute of Health(Grant Nos.:1R15EB014546-01A1,K25AG061282).

摘　　要：A two-photon near infrared(NIR)fluorescence turn-on sensor with high selectivity and sensitivity for Zn^(2+)detection has been developed.This sensor exhibits a large Stokes'shift(-300 nm)and can be excited from 900 to 1000 nm,with an emission wavelength of-785 nm,making it ideal for imaging in biological tissues.The sensor's high selectivity for Zn^(2+)over other structurally similar cations,such as Cd^(2+),makes it a promising tool for monitoring zinc ion levels in biological systems.Given the high concentration of zinc in thrombi,this sensor could provide a useful tool for in vivo thrombus imaging.

关 键 词：NEAR-INFRARED Molecular imaging THROMBUS STROKE 

分 类 号：R313[医药卫生—基础医学] O657.3[理学—分析化学]