Effect of Ta_(2)O_(5)nanoparticles on bioactivity,composition,structure,in vitro and in vivo behavior of PEO coatings on Mg-alloy  

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作  者:D.V.Mashtalyar I.M.Imshinetskiy V.V.Kashepa K.V.Nadaraia M.A.Piatkova A.I.Pleshkova K.A.Fomenko A.Yu.Ustinov S.L.Sinebryukhov S.V.Gnedenkov 

机构地区:[1]Institute of Chemistry,Far Eastern Branch,Russian Academy of Sciences,Vladivostok,690022,Russia [2]Far Eastern Federal University,Vladivostok,690950,Russia [3]Regional Clinical Dermatovenerological Dispensary,Vladivostok,690033,Russia

出  处:《Journal of Magnesium and Alloys》2024年第6期2360-2379,共20页镁合金学报(英文)

基  金:The formation of coatings,as well as SEM,EDS,FTIR spectroscopy and mechanical studies was supported by Russian Science Foundation grant No.22-73-10149,https://rscf.ru/project/22-73-10149/;The electrochemical studies,in vitro and in vivo studies was supported by the Russian Science Foundation grant No.23-13-00329,https://rscf.ru/project/23-13-00329/。

摘  要:The present study investigates the physical and chemical characteristics,behavior in vitro and in vivo,and biocompatibility of coatings containing Ta_(2)O_(5),which are obtained by plasma electrolytic oxidation(PEO)on MA8 magnesium alloy.The obtained coatings demonstrate in vivo biocompatibility and in vitro bioactivity.Compared to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the development of apatite in simulated body fluid,suggesting that the inclusion of nanoparticles improves bioactivity of the coatings.It was found that incorporation of Ta_(2)O_(5)nanoparticles increases roughness and porosity of the formed layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in vivo.Based on in vivo studies,these coatings also provide favorable tissue response and minimal inflammatory reaction in comparison with the bare magnesium alloy due to protection of living tissues from deleterious corrosion events of magnesium implant such as local alkalization and intense hydrogen evolution.The results obtained in the present study concluded biocompatibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles making them a promising protective layer for biodegradable magnesium implants.

关 键 词:Plasma electrolytic oxidation Bioactive coatings Tantalum pentoxide Simulated body fluid(SBF) Apatite formation HISTOLOGY 

分 类 号:TG174.4[金属学及工艺—金属表面处理] R318.08[金属学及工艺—金属学]

 

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