脐带间充质干细胞对2型糖尿病的免疫调节作用  

Immunomodulatory effect of umbilical cord mesenchymal stem cells on type 2 diabetes mellitus

作　　者：陈春兰 叶美仪 潘雨薇 袁佳 周朋君 Chen Chunlan;Ye Meiyi;Pan Yuwei;Yuan Jia;Zhou Pengjun(Department of Pharmacology,School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong Province,China;Department of Preventive Healthcare,Affiliated TCM Hospital of Guangzhou Medical University,Guangzhou 510130,Guangdong Province,China;Department of Rehabilitation Medicine,Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Foshan 528200,Guangdong Province,China;Biomedical Base,College of Life Science and Technology,Jinan University,Guangzhou 510632,Guangdong Province,China)

机构地区：[1]广东药科大学药学院药理系,广东省广州市510006 [2]广州医科大学附属中医医院治未病科,广东省广州市510130 [3]广东省中西医结合医院康复科,广东省佛山市528200 [4]暨南大学生科院生物医药基地,广东省广州市510632

出　　处：《中国组织工程研究》2025年第23期5031-5040,共10页Chinese Journal of Tissue Engineering Research

基　　金：广州市基础与应用基础一般项目(2023A04J1143),项目负责人:周朋君;广东省中医药重点学科(临床类)建设项目([2021] No.129),项目负责人:袁佳;佛山市“十四五”医学高水平重点专科建设项目(FSGSP145086),项目负责人:袁佳。

摘　　要：背景:脐带间充质干细胞具有免疫调节功能和多向分化潜能,能够积极改善2型糖尿病的慢性低度炎症状态,对阻止2型糖尿病疾病进展具有重要意义。目的:综述脐带间充质干细胞通过免疫调节作用治疗2型糖尿病的研究进展。方法:以“脐带间充质干细胞,间充质干细胞,2型糖尿病,免疫,胰岛素抵抗,炎症”等为中文检索词,以“umbilical cord mesenchymal stem cells,UC-MSCs,mesenchymal stem cells,MSCs,type 2 diabetes mellitus,T2DM,immunity,insulin resistance,inflammation”等为英文检索词,在中国知网、Web of Science和PubMed数据库筛选相关的综述、研究型论文和论著,根据纳入标准和排除标准整理出88篇论文进行归纳总结。结果与结论:脐带间充质干细胞可通过免疫调节作用降低机体炎症反应、诱导巨噬细胞向M2型极化,增加靶器官对胰岛素敏感性,改善胰岛素抵抗,缓解胰岛β细胞功能障碍等,进而有效延缓2型糖尿病发生发展。但在脐带间充质干细胞移植成为常规治疗手段之前,还需要进行大规模的基础与应用基础研究以确定其最佳治疗方案及疗效。BACKGROUND:Umbilical cord mesenchymal stem cells present immunomodulatory function and multidirectional differentiation potential.Umbilical cord mesenchymal stem cells can actively improve the chronic low-grade inflammation state in type 2 diabetes mellitus and which is important for preventing the development of type 2 diabetes mellitus progression.OBJECTIVE:To review the research progress of umbilical cord mesenchymal stem cells in the treatment of type 2 diabetes mellitus through immunomodulatory effect.METHODS:Using“umbilical cord mesenchymal stem cells,UC-MSCs,mesenchymal stem cells,MSCs,type 2 diabetes mellitus,T2DM,immunity,insulin resistance,inflammation”as Chinese and English search terms,articles were searched on CNKI,Web of Science and PubMed databases.Relevant reviews,research papers and theses were screened and 88 papers were collected for summarization based on the inclusion and exclusion criteria.RESULTS AND CONCLUSION:Umbilical cord mesenchymal stem cells can effectively delay the occurrence and development of type 2 diabetes mellitus by reducing inflammatory response,inducing macrophages to M2 polarization,increasing the sensitivity of target organs to insulin,improving insulin resistance,and alleviating the dysfunction of islet beta cells through immune regulation.However,before umbilical cord mesenchymal stem cell transplantation can become a routine treatment,large-scale basic and applied basic research is needed to determine the optimal treatment regimen and efficacy.

关 键 词：脐带间充质干细胞 2型糖尿病 免疫 胰岛素抵抗 炎症 巨噬细胞 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R587.1