胶质淋巴系统研究的知识图谱与趋势可视化分析  

Visualization analysis of knowledge map and trends in glymphatic system research

作　　者：马星怡 李惠菁 李涓 钟冬灵[1] 张源 唐红 李雨谿 金荣疆 Ma Xingyi;Li Huijing;Li Juan;Zhong Dongling;Zhang Yuan;Tang Hong;Li Yuxi;Jin Rongjiang(School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;SCollege of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611135,Sichuan Province,China;School of Acupuncture and Massage,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China)

机构地区：[1]成都中医药大学养生康复学院,四川省成都市610075 [2]成都中医药大学临床医学院,四川省成都市610075 [3]成都中医药大学附属四川省康复医院,四川省成都市611135 [4]成都中医药大学针灸推拿学院,四川省成都市610075

出　　处：《中国组织工程研究》2025年第23期5051-5060,共10页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金青年科学基金项目(82305363),项目负责人:李雨谿;国家自然科学基金面上项目(82374559),项目负责人:金荣疆;四川省自然科学基金项目(2023NSFSC1824),项目负责人:李雨谿;中国博士后科学基金第73批面上资助项目(2023MD734102),项目负责人:李雨谿。

摘　　要：背景:大脑的代谢废物清除功能对于维持神经稳态极为关键,代谢废物积累导致的神经稳态失衡是许多中枢神经系统疾病的共同病理学特征。近年来,围绕胶质淋巴系统的研究逐渐成为神经系统领域的研究热点。目的:旨在通过构建胶质淋巴系统研究的知识图谱,可视化地分析该领域的研究现状、热点及其未来的发展趋势。方法:采用Cite Space、VOSviewer软件及R语言环境下的Bibliometrix工具包,对2012年1月至2024年3月Web of Science核心合集数据库中与胶质淋巴系统相关的原始文献进行深入可视化分析,分析内容包括作者、机构、国家、期刊、关键词和共被引文献等。结果与结论:研究共纳入687篇相关文章,该领域发文量逐年增长,近3年呈现爆发性增长趋势;该研究领域发文量第一的国家、机构、作者分别是美国、美国罗切斯特大学和罗切斯特大学的Maiken Nedergaard教授,发文量第一的期刊是《JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM》,高频、高中心性关键词主要围绕脑脊液流体动力学等作用机制、阿尔茨海默症等神经系统疾病、扩散张量成像等影像学技术等方面,共被引频次最高的文献是一篇胶质淋巴系统的经典综述论文。上述结果表明,胶质淋巴系统的研究是一个新兴而活跃的领域,目前已受到国内外的广泛关注并逐渐从理论研究向临床实践扩展。BACKGROUND:The clearance pathway of metabolic waste in the brain is crucial for maintaining neural homeostasis.The accumulation of metabolic waste disrupts this equilibrium,representing a common pathological feature of many central nervous system diseases.In recent years,research focusing on the glymphatic system has emerged as a hotspot in the nervous system field.OBJECTIVE:To construct a knowledge map of glymphatic system research,visually analyze the current state of research,main hotspots,and future development trends within this area.METHODS:Utilizing CiteSpace,VOSviewer,and the Bibliometrix package in the R language environment,this study conducted an in-depth visual analysis of glymphatic system-related literature from the Web of Science Core Collection database,spanning from January 2012 to March 2024.This analysis included authors,institutions,countries,journals,keywords,and co-citation frequencies.RESULTS AND CONCLUSION:A total of 687 related articles were included in this study.The number of publications in this field increased year by year,showing an explosive growth trend in the past three years.The countries,institutions,and authors with the largest number of publications in this research field were the United States,University of Rochester,and Professor Maiken Nedergaard.The journal with the highest number of publications was JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.The high-frequent and high-central keywords mainly focused on the mechanism such as cerebrospinal fluid hydrodynamics,neurological diseases such as Alzheimer’s disease,and imaging techniques such as diffusion tensor imaging.The literature with the highest co-citation frequency was a classic review of the glymphatic system.The above results show that the research of glymphatic system is an emerging and active field,which has attracted wide attention at home and abroad and gradually expand from theoretical research to clinical practice.

关 键 词：胶质淋巴系统 研究现状 研究热点 发展趋势 可视化图谱 Cite Space VOSviewer R语言 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R741