新疆维吾尔自治区肺结核合并糖尿病患者治疗转归影响因素分析  

Analysis of influencing factors of treatment outcomes in patients with pulmonary tuberculosis complicated with diabetes mellitus in Xinjiang Uygur Autonomous Region

作　　者：黄涛 菅辉勇[1,2] 王新旗 刘年强 依帕尔·艾海提[3] 王明哲[3] 加依那提·金格斯[1] 王森路 Huang Tao;Jian Huiyong;Wang Xinqi;Liu Nianqiang;Yipar Aihaiti;Wang Mingzhe;Jiayinati Jingesi;Wang Senlu(School of Public Health,Xinjiang Medical University,Urumqi 830017,China;Center for Disease Control and Prevention of Bayinguoleng Mongolia Autonomous Prefecture,Korla 841499,China;Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region,Urumqi 830002,China)

机构地区：[1]新疆医科大学公共卫生学院,乌鲁木齐830017 [2]新疆维吾尔自治区巴音郭楞蒙古自治州疾病预防控制中心,库尔勒841499 [3]新疆维吾尔自治区疾病预防控制中心,乌鲁木齐830002

出　　处：《中国防痨杂志》2024年第9期1083-1088,共6页Chinese Journal of Antituberculosis

基　　金：新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(WJWY-202242);新疆维吾尔自治区自然科学基金(2023D01C57);新疆维吾尔自治区科学技术协会青年人才托举工程项目(RCTJ42);“天山英才”医药卫生高层次人才培养计划(TSYC202301B166)

摘　　要：目的:分析新疆维吾尔自治区(简称“新疆”)肺结核合并糖尿病患者(简称“共病患者”)特征及影响治疗结果的因素,为结核病防控工作提供科学依据。方法:通过“中国疾病预防控制信息系统”的子系统“结核病管理信息系统”获得2021年1月1日至2022年12月31日新疆报告的结核病流行病学信息,对其中的共病患者与同期管理的未合并糖尿病肺结核患者的特征进行对照比较,对影响共病患者治疗转归的因素进行分析。结果:2021—2022年,新疆共登记肺结核患者36729例,其中未合并糖尿病的肺结核患者34286例,共病患者2443例。多因素logistic回归分析结果显示,年龄≥65岁(OR=3.826,95%CI:1.942~7.536)、复治(OR=1.809,95%CI:1.264~2.588)、涂阳(OR=1.620,95%CI:1.183~2.218)、治疗2个月末痰涂片未阴转(OR=1.591,95%CI:1.057~2.394)为治疗转归发生不良结局的危险因素。结论:新疆共病患者中,导致不良治疗结局的危险因素包括年龄≥65岁、复治、涂阳、治疗2个月末痰涂片未阴转。对于共病患者,需要强化随访管理,提高治疗依从性,确保治疗效果,以降低不良转归发生的比例。Objective:To analyze the characteristics and factors affecting treatment outcomes of pulmonary tuberculosis-diabetes mellitus(PTB-DM)in Xinjiang Uygur Autonomous Region(hereinafter referred to as Xinjiang),to provide scientific basis for tuberculosis prevention and control.Methods:Epidemiological data of reported tuberculosis cases in Xinjiang from January 1,2021 to December 31,2022 were obtained through the“Tuberculosis Management Information System”,a subsystem of the“Chinese Disease Prevention and Control Information System”,and a descriptive analysis was conducted.Characteristics of PTB-DM patients and PTB patients without DB registered at the same time were compared.The factors affecting treatment outcomes of PTB-DM patients were analyzed.Results:Among 36729 patients registered in Xinjiang in 2021—2022,34286 were patients with PTB alone and 2443 were PTB-DM patients.Multivariable logistic regression analysis showed that age≥65 years(OR=3.826,95%CI:1.942-7.536),retreatment(OR=1.809,95%CI:1.264-2.588),smear positive(OR=1.620,95%CI:1.183-2.218),and sputum smear not turning negative at the end of 2 months’treatment(OR=1.591,95%CI:1.057-2.394)were risk factors for adverse treatment outcomes.Conclusion:For patients with PTB-DM in Xinjiang,risk factors of adverse treatment outcomes included age≥65 years,retreatment,smear positive,and sputum smear not turning negative at the end of 2 months’treatment.Thus,we should strengthen follow-up management of PTB-DM patients,improve their treatment compliance,ensure treatment effectiveness,and reduce the occurrence of adverse outcomes.

关 键 词：结核 肺 糖尿病 治疗结果 因素分析 统计学 

分 类 号：R521[医药卫生—内科学] R587.1[医药卫生—临床医学]