智能响应性材料在股骨头坏死精准修复中的应用  

Application of smart responsive materials in the precise repair of osteonecrosis of the femoral head

作　　者：陈浩 席洪钟 薛鹏 何帅 谈小雪 孙光权[1] 刘锌[1] 江晓红[2] 杜斌[1] Chen Hao;Xi Hong-Zhong;Xue Peng;He Shuai;Tan Xiao-Xue;Sun Guang-Quan;Liu Xin;Jiang Xiao-Hong;Du Bin(Department of Orthopedics and Traumatology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210029,China;Academy of Chemical Engineering and Technology,Nanjing University of Science and Technology,Nanjing,Jiangsu 210094,China)

机构地区：[1]南京中医药大学附属医院骨伤科,江苏南京210029 [2]南京理工大学化工学院,江苏南京210094

出　　处：《解放军医学杂志》2024年第7期841-847,共7页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金面上项目(82074471);国家重点研发计划“政府间国际科技创新合作”重点专项(2022YFE0196800);江苏省卫生健康委科研项目(K2019027);江苏省高校优势学科建设工程资助项目(035062005001)。

摘　　要：股骨头坏死(ONFH)是骨科常见病,在疾病早期进行保髋治疗对于中青年患者具有重要的临床意义。然而,ONFH的修复具有异质性,导致个体间的保髋疗效存在差异。目前,保髋领域现有的组织工程支架均属于不可调控支架,在植入后无法根据股骨头内修复情况进行精准调控,难以满足精准修复的需求。智能响应性材料具有良好的生物安全性和自我反馈能力,将其与治疗药物结合构建成刺激-响应性药物递送系统,为ONFH的精准修复提供了新的选择。本文对国内外智能响应性材料的研究进展进行综述,并根据各种材料的响应原理及ONFH的修复特点,探讨活性氧响应性、剪切应力响应性、光/磁响应性等多种智能响应性材料在ONFH精准修复领域的应用前景,以期为ONFH的精准治疗提供新的思路。Osteonecrosis of the femoral head(ONFH)is a common orthopedic disease,and hip preservation surgery has high clinical value in the early stages of ONFH,especially for young and middle-aged patients.However,the repair of ONFH is heterogeneous,leading to inter-individual variations in the efficacy of hip preservation.Currently,the existing tissue-engineered scaffolds in the field of hip preservation are uncontrollable after implantation,making it difficult to achieve precise repair.Smart responsive materials have good biocompatibility and self-feedback capability.By combining them with therapeutic drugs to construct stimulus-responsive drug delivery systems,new possibilities are provided for the precise repair of ONFH.This paper reviews the research progress of smart responsive materials at home and abroad.Based on the response principles of various materials and the repair characteristics of ONFH,the application prospects of various smart responsive materials such as reactive oxygen speciesresponsive,fluid shear stress-responsive,and light/magnetic-responsive materials are discussed and prospected in the field of precise repair for ONFH,providing new ideas for the precise treatment of ONFH.

关 键 词：智能响应性材料 股骨头坏死 修复异质性 精准修复 应用展望 

分 类 号：R681.8[医药卫生—骨科学]