慢性疼痛患者下行疼痛调制系统的磁共振成像研究进展  

Progress in magnetic resonance imaging studies of the descending pain modulation system in patients with chronic pain

作　　者：周慧玲 雷婷 陈莉[1] 杜勇[1] ZHOU Huiling;LEI Ting;CHEN Li;DU Yong(Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院放射科,南充637000

出　　处：《磁共振成像》2024年第8期189-193,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家临床重点专科建设项目(编号:[2023]87);南充市校科技战略合作专项(编号:20SXZRKX0011)。

摘　　要：慢性疼痛是一种复杂的体验,给患者和社会都带来了重大负担。在慢性疼痛的神经机制研究中,虽然研究者们常常关注疼痛的感知和控制相关脑区,但往往忽视了下行疼痛调制系统(descending pain modulation system,DPMS)相关脑区在慢性疼痛中结构及功能改变对疼痛感知的抑制和促进作用。本文就慢性疼痛患者DPMS的结构及功能改变的最新MRI研究进展予以综述,旨在探究DPMS的生理和病理机制,进一步深化对慢性疼痛的理解。Chronic pain is a complex experience that significantly burdens both patients and society.Research on the neural mechanisms of chronic pain typically focus on the areas related to the perception and control of pain.However,there is often less attention to the structural and functional changes in the brain regions associated with the descending pain modulation system.These areas play key roles in both inhibiting and facilitating pain perception.This article reviews the latest MRI research progress on the structural and functional changes in the descending pain modulation system in patients with chronic pain,aiming to explore the physiological and pathological mechanisms of DPMS and further deepen the understanding of chronic pain.

关 键 词：慢性疼痛 下行疼痛调制系统 结构磁共振成像 功能磁共振成像 扩散磁共振成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741.02[医药卫生—诊断学]