MXene基水凝胶在创面修复领域的应用  

Application of MXene-based hydrogels in wound repair

作　　者：何蕊 李重一 王瑞瑶 曾丹 范代娣[1] He Rui;Li Chongyi;Wang Ruiyao;Zeng Dan;Fan Daidi(School of Chemical Engineering,Shaanxi Key Laboratory of Degradable Biomedical Materials,Shaanxi R&D Center of Biomaterials and Fermentation Engineering,Northwest University,Xi’an 710127,Shaanxi Province,China)

机构地区：[1]西北大学化工学院,陕西省可降解生物医用材料重点实验室,陕西省生物材料与发酵工程技术研究中心,陕西省西安市710127

出　　处：《中国组织工程研究》2025年第16期3486-3493,共8页Chinese Journal of Tissue Engineering Research

基　　金：科技部国家重点研发计划项目(2019YFA0905200),项目负责人:范代娣;国家自然科学基金青年项目(22108226),项目负责人:曾丹;陕西省自然科学基础研究计划青年项目(2021JQ-439),项目负责人:曾丹。

摘　　要：背景:MXene基水凝胶是一类纳米复合的多功能性水凝胶材料,在慢性创面(如糖尿病足、压疮、癌症及外伤性溃疡等)修复领域有广阔的应用前景。目的:综述MXene基水凝胶的优势及其在创面修复领域的应用和相关作用机制。方法:检索中国知网、维普、PubMed、Science Direct数据库中收录的文章,文献检索时限为2010年1月至2023年10月,中文检索关键词为“MXene,水凝胶,组织工程应用,创面修复”,英文检索关键词为“MXene,Hydrogel,Wound repair”,最终选取符合标准的70篇文献进行综述。结果与结论:MXene基水凝胶在创面组织工程应用中具有优异的力学、导电和光热性能及生物相容性和抗菌性等生物学功效,可以与其他有机物质和无机物质相结合,在水凝胶中产生更大的治疗作用。含有MXene的水凝胶可以结合创面监测、药物递送和缓释以及光热治疗等方式应用于皮肤创面。尽管MXene基水凝胶复合材料的设计和制备已经取得一些良好进展,但仍处于基础研究阶段,缺乏临床验证其功效性和安全性,具有很大发展潜力和应用空间。BACKGROUND:MXene-based hydrogel is a kind of nano-composite multifunctional hydrogel material,which has broad application prospects in the field of chronic wound repair,such as diabetic foot,pressure sore,cancer,and traumatic ulcer.OBJECTIVE:To review the advantages of MXene-based hydrogels and their application and related action mechanism in wound repair.METHODS:The articles included in CNKI,VIP,PubMed,and Science Direct databases were searched from January 2010 to October 2023.The key words were“MXene,hydrogel,tissue engineering application,wound repair”in Chinese and“MXene,hydrogel,wound repair”in English.Finally,70 articles that met the criteria were selected for review.RESUILTS AND CONCLUSION:MXene-based hydrogels have excellent mechanical,electrical,photo-thermal properties,biocompatibility,and antibacterial effects in wound tissue engineering,and can be combined with other organic and inorganic substances to produce greater therapeutic effects in hydrogel.MXene-based hydrogels can be applied to skin wounds in combination with wound monitoring,drug delivery and release,and photothermal therapy.Despite some progresses in the design and preparation of MXene-based hydrogel composites,they are still in the fundamental research stage.There is a lack of clinical validation regarding their effectiveness and safety,but they hold great potential for development and application.

关 键 词：纳米功能材料 MXene 水凝胶 创面修复 生物相容性 创面监测 药物缓释 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R-1