香蜂花醇提物对一次性力竭运动引起的大鼠心肌损伤的保护作用及其机制  

Protective Effects and Mechanisms of Melissa officinalis Extract on Rat Myocardial Injury from Acute Exhaustive Exercise

作　　者：邓晶[1] 柳志雄 Deng Jing;Liu Zhixiong(Yichun Vocational Technical College,Yichun,336000)

机构地区：[1]宜春职业技术学院,宜春336000

出　　处：《分子植物育种》2024年第16期5485-5491,共7页Molecular Plant Breeding

摘　　要：香蜂花(Melissa officinalis L.)是一种具有广泛药理活性的药用植物,含有多种对人体有益的活性化合物,香蜂花的心脏保护作用受到了广泛关注。本研究旨在探讨香蜂花醇提物(Melissa officinalis L.ethanol extract,MOEE)对一次性力竭运动(EE)引起的大鼠心肌损伤的保护作用及其潜在机制。本研究比较了对照组(C组)、EE组以及接受不同剂量MOEE处理的EE大鼠(EE+L-MOEE,EE+M-MOEE,EE+H-MOEE)的心肌损伤指标、能量代谢参数、氧化应激反应和NLRP3炎性体通路的活性。结果显示,与EE组相比,MOEE处理能显著提高心肌的能量代谢水平,降低乳酸(LA)和尿素氮(BUN)水平,提升心肌SOD和CAT活性,减少MDA积累,抑制NLRP3炎性体通路的激活,从而减轻心肌细胞焦亡。这些发现表明,香蜂花醇提物通过改善氧化应激反应和抑制NLRP3炎性体通路,对EE引起的心肌损伤具有显著的保护作用。本研究为香蜂花醇提物在预防和治疗运动相关心脏损伤中的应用提供了实验依据。Lemon balm(Melissa officinalis L.)is a medicinal plant with a wide range of pharmacological activities,containing numerous beneficial bioactive compounds.The cardioprotective effects of lemon balm have attracted widespread attention.This study aimed to investigate the protective effects and potential mechanisms of Melissa officinalis L.ethanol extract(MOEE)on rat myocardial injury induced by exhaustive exercise(EE).The study compared myocardial injury indicators,energy metabolism parameters,oxidative stress responses,and NLRP3 inflammasome pathway activity among the control group(C group),EE group,and EE rats treated with different doses of MOEE(EE+L-MOEE,EE+M-MOEE,EE+H-MOEE).The results showed that compared to the EE group,MOEE treatment significantly improved myocardial energy metabolism levels,reduced lactate(LA)and blood urea nitrogen(BUN)levels,enhanced myocardial SOD and CAT activity,decreased MDA accumulation,and inhibited the activation of the NLRP3 inflammasome pathway,thereby mitigating myocardial cell pyroptosis.These findings suggest that lemon balm ethanol extract exerts a significant protective effect on myocardial injury induced by EE through improving oxidative stress response and inhibiting the NLRP3 inflammasome pathway.This study provides experimental evidence for the application of lemon balm ethanol extract in pre venting and treating exer-cise-related cardiac injury.

关 键 词：香蜂花(Melissa officinalis L.) 香蜂花醇提物 力竭运动 心肌损伤 氧化应激 NLRP3炎性体 

分 类 号：R285.5[医药卫生—中药学]