抑制IgE与肥大细胞FcεRⅠ受体结合防治变应性疾病的研究进展  

Advances in the prevention and treatment of allergic diseases by inhibiting the binding of IgE to FcεRⅠreceptor on mast cell

作　　者：赵晶 刘思麟(综述) 彭华(审校) ZHAO Jing;LIU Silin;PENG Hua(Graduate School,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China;The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,Guangdong,China;Department of Otolaryngology Head and Neck Surgery,General Hospital of Southern Theater Command,Guangzhou 510010,Guangdong,China)

机构地区：[1]广州中医药大学研究生院,广州510006 [2]南方医科大学第一临床医学院,广州510515 [3]南部战区总医院耳鼻咽喉头颈外科,广州510010

出　　处：《医学研究与战创伤救治》2024年第5期543-548,共6页Journal of Medical Research & Combat Trauma Care

基　　金：广东省自然科学基金(2023A1515010268)。

摘　　要：变应性疾病是全世界影响最广泛的慢性疾病之一,肥大细胞是Ⅰ型变态反应最主要的终末效应细胞,IgE与其肥大细胞表面高亲和力受体FcεRⅠ的结合是启动肥大细胞级联反应释放炎性介质的关键步骤。阻断或抑制肥大细胞膜上IgEFcεRⅠ的交联,从而影响肥大细胞活化已成为变应性疾病防治的有效策略和研究热点。文章从阻断IgE抗体、IgE-FcεRⅠ结合以及FcεRⅠ受体三个方面就靶向肥大细胞上IgE和FcεRⅠ防治变应性疾病的策略及相关机制进行综述。Allergic diseases are one of the most widespread chronic diseases in the world.Mast cells are the most predominant end-effector cells of type I allergic reaction.The binding of IgE to its high affinity receptor FcεRⅠon the surface of mast cells is a key step to initiate the cascade reaction of mast cell to release inflammatory mediators.Blocking or inhibiting the cross-linking of IgE-FcεRI on hypertrophic cell membrane to affect mast cell activation has become an effective strategy and research focus for the prevention and treatment of allergic diseases.This article reviews the strategies and related mechanisms of targeting IgE and FεRⅠon mast cells to prevent allergic diseases from three aspects:blocking IgE antibody,IgE-FεRⅠbinding and FεRⅠreceptor.

关 键 词：IGE FcεRⅠ 肥大细胞 变应性疾病 

分 类 号：R392[医药卫生—免疫学]