γ-干扰素试验在结核病诊断中的临床应用价值  

Clinical application value of gamma-interferon test in diagnosis of tuberculosis

作　　者：杨宇溪[1] 张秀琴[1] 杨宇舟[2] 李春梅 李颖 黄灏莹 白雪晶 YANG Yuxi;Zhang Xiuqin;YANG Yuzhou;LI Chunmei;LI Ying;Huang Haoying;Bai Xuejing(Department of Clinical Laboratory,Yuxi People's Hospital/Sixth Affiliated Hospital of Kunming Medical University,Yuxi Yunnan 653100,China;Nuclear Medicine Department,First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]玉溪市人民医院/昆明医科大学第六附属医院医学检验科,云南玉溪653100 [2]昆明医科大学第一附属医院核医学科,云南昆明650032

出　　处：《云南医药》2024年第4期59-61,共3页Medicine and Pharmacy of Yunnan

基　　金：云南省教育厅科学研究基金项目(2020J0237)。

摘　　要：目的分析CLIA检测γ-干扰素试验诊断结核病的临床应用价值。方法选取2023年5月-2023年9月在本院接受检查的疑似结核病患者1616例,以临床最终诊断结果为金标准,判断全自动化学发光法检测γ-干扰素试验在结核病诊断中的诊断效能。结果临床最终诊断结果显示,阳性患者916例,阴性患者700例。γ-干扰素试验结果显示,阳性患者908例,阴性患者708例。CLIA检验γ-干扰素试验在肺外结核中的阳性检出率较高,但与临床最终诊断结果比较差异有统计学意义(P<0.05);在结核病、肺结核、呼吸道疾病、肺部炎症疾病的阳性检出率与临床最终诊断结果比较差异无统计学意义(P>0.05);在结核病中的敏感度、特异度、准确度与临床最终诊断结果比较差异无统计学意义(P>0.05)。结果采用CLIA检测γ-干扰素试验可对结核病进行诊断,可明确患者为结核病或非结核疾病,并且在结核病的诊断中具有较高的敏感度、特异性。Objective To analyze the clinical application value of detection of fully automated chemiluminescence assay(CLIA)γ-interferon test in the diagnosis of tuberculosis.Methods A total of 1616 suspected tuberculosis patients who were examined in our hospital from May 2023 to September 2023 were selected,and the final clinical diagnosis results were taken as the gold standard to judge the automatic chemiluminescence detectionγ-interferon test in the diagnosis of tuberculosis.Results The final clinical diagnosis showed that 916 patients were positive and 700 patients were negative.The results ofγ-interferon test showed that 908 patients were positive and 708 patients were negative.The positive detection rate of CLIAγ-interferon test in tuberculosis was relatively high,but there was statistically significant compared with the final clinical diagnosis results(P<0.05);There was no significant difference between the positive detection rate of tuberculosis,pulmonary tuberculosis,respiratory diseases and pulmonary inflammatory diseases and the final clinical diagnosis results(P>0.05);There was no significant difference between the sensitivity,specificity and accuracy of tuberculosis and the final clinical diagnosis(P>0.05).Conclusions The use of fully automated chemiluminescence methodγ-interferon test can diagnose tuberculosis,can identify patients with tuberculosis or non-tuberculosis diseases,and has a high sensitivity and specificity in the diagnosis of tuberculosis.

关 键 词：全自动化学发光法 γ-干扰素试验 结核病 诊断效能 

分 类 号：R52[医药卫生—内科学] R446.6[医药卫生—临床医学]