老年衰弱发病机制的研究进展  

Research progress on the pathogenesis of geriatric frailty

作　　者：曾炜 管张烁 沈大鹏(综述) 沈洁淼(审校) ZENG Wei;GUAN Zhangshuo;SHEN Dapeng;SHEN Jiemiao(School of Pediatrics,Nanjing Medical University,Nanjing,Jiangsu 211166,China;The Second Clinical Medical School,Nanjing Medical University,Nanjing,Jiangsu 211166,China;School of Nursing,Nanjing Medical University,Nanjing,Jiangsu 211166,China)

机构地区：[1]南京医科大学儿科学院,江苏南京211166 [2]南京医科大学第二临床医学院,江苏南京211166 [3]南京医科大学护理学院,江苏南京211166

出　　处：《现代医药卫生》2024年第16期2855-2858,2872,共5页Journal of Modern Medicine & Health

基　　金：江苏省高等学校大学生创新创业训练计划项目(202310312074Y)。

摘　　要：老年衰弱是老年人面临的一种复杂综合征,其特征是机体多器官系统生理储备降低和失调使机体自稳能力下降,导致日常活动能力的减弱和生活质量的下降。随着人口老龄化,衰弱正逐渐成为威胁老年人群健康的公共卫生问题,严重影响老年人的生活质量和临床结局。老年衰弱的发病机制是一个复杂过程,包括炎症反应、细胞衰老、肠道菌群紊乱、胰岛素抵抗、神经内分泌失调等多方面的影响。该文对老年衰弱发病机制进行了综述,为识别衰弱危险因素、制定相应预防和干预策略、延缓老年衰弱、改善老年人生活质量提供线索和依据。Geriatric frailty is a complex syndrome faced by the elderly,which is characterized by the decrease of physiological reserve and imbalance of multiple organ systems,which leads to the decrease of self-stability ability,the weakening of daily activity ability and the decline of quality of life.With the aging of the population,frailty is gradually becoming a public health problem that threatens the health of the elderly,seriously affecting the quality of life and clinical outcomes of the elderly.The pathogenesis of geriatric frailty is a complex process,including inflammatory response,cell senescence,intestinal flora disorder,insulin resistance,neuroendocrine disorders and other effects.This article reviews the pathogenesis of frailty in the elderly,and provides clues and basis for identifying risk factors for frailty,formulating corresponding prevention and intervention strategies,delaying frailty in the elderly,and improving the quality of life of the elderly.

关 键 词：老年衰弱 细胞衰老 肠道菌群 胰岛素抵抗 神经内分泌激素 综述 

分 类 号：R592[医药卫生—老年医学]