辅助性T细胞17/调节性T细胞及维甲酸相关孤儿受体γt/叉头框转录因子P3失衡在妊娠相关疾病中的研究进展  

Research progress of T helper cell 17/regulatory T cell and retinoic acid-related orphan receptorγt/forkhead box transcription factor P3 imbalance in pregnancy-related diseases

作　　者：杨春燕 冯晓玲[2] Yang Chunyan;Feng Xiaoling(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Second Department of Gynecology,Frist Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科二科,哈尔滨150040

出　　处：《中国医药》2024年第9期1436-1440,共5页China Medicine

基　　金：国家自然科学基金(81973894、82174421);黑龙江省自然科学基金(ZD2021H006)。

摘　　要：在免疫学领域,妊娠相当于一次成功的半同种移植现象,母体对半异体胎儿的免疫耐受情况关乎妊娠的结局。辅助性T细胞17(Th17)和调节性T细胞(Treg)是最新发现的CD^(+)_(4)T淋巴细胞亚群,相关转录因子维甲酸相关孤儿受体γt和叉头框转录因子P3的表达水平与Th17/Treg之间的平衡密切相关。Th17/Treg免疫失衡会导致母体对胎儿的异常攻击,造成母胎耐受紊乱,并与复发性流产、先兆子痫、妊娠糖尿病等病理妊娠有关。In the field of immunology,pregnancy is equivalent to a successful semi-allograft phenomenon,and the maternal immune tolerance to the semi-allograft fetus is related to the outcome of pregnancy.Helper T cells 17(Th17)and regulatory T cell(Treg)are newly discovered subsets of CD^(+)_(4)T lymphocytes.The expression levels of related transcription factor retinoic acid-related orphan receptorγt and forkhead box transcription factor P3 are closely related to the balance between Th17/Treg.The Th17/Treg immune imbalance can lead to abnormal maternal attack on the fetus,resulting in maternal-fetal tolerance disorder,and is related to recurrent miscarriage,preeclampsia,gestational diabetes mellitus and other pathological pregnancy.

关 键 词：妊娠相关疾病 辅助性T细胞17 调节性T细胞 维甲酸相关孤儿受体γt 叉头框转录因子P3 

分 类 号：R714.25[医药卫生—妇产科学]