血清缺氧诱导因子-1α和白细胞介素-4与支气管扩张并发肺部感染患者病情严重程度及预后的关系  

Relationship between serum HIF-1αIL-4 and severity and prognosis in patients with bronchiectasis complicated with pulmonary infection

作　　者：周峥雷 宋璠 Zhou Zhenglei;Song Fan(Department of Shaanxi Aerospace Hospital,Xi′an 710025,China)

机构地区：[1]陕西航天医院呼吸与危重症医学科,西安710025

出　　处：《山西医药杂志》2024年第11期823-827,共5页Shanxi Medical Journal

摘　　要：目的分析血清缺氧诱导因子-1α(HIF-1α)、白细胞介素-4(IL-4)与支气管扩张并发肺部感染患者病情严重程度及预后的关系。方法选择本院自2019年4月至2021年5月期间收诊的200例支气管扩张患者,根据其是否并发肺部感染,分成感染组(n=122)与未感染组(n=78),对比2组患者HIF-1α、IL-4表达水平,再根据感染组病情严重程度分成为轻、中、重度感染,分析不同感染程度患者HIF-1α、IL-4表达水平,并根据感染组预后情况将其分成预后良好与预后不良,对比不同预后支气管扩张并发肺部感染患者各临床资料,经Logistic回归分析影响支气管扩张并发肺部感染预后不良的危险因素,并采用受试者工作特征(ROC)曲线分析血清HIF-1α、IL-4对支气管扩张并发肺部感染患者预后的评估价值。结果感染组HIF-1α、IL-4水平高于未感染组(P<0.05);不同感染程度支气管扩张患者HIF-1α、IL-4水平呈现轻度感染组<中度感染组<重度感染组(P<0.05);不同预后支气管扩张并发肺部感染患者在肺功能第1秒用力呼气容积(FEV1)、改良基因MRC呼吸困难指数(mMRC)评分、HIF-1α、IL-4方面比较差异具有统计学意义(P<0.05);行Logistic回归分析得出HIF-1α、IL-4高表达是影响支气管扩张并发肺部感染预后不良的危险因素(P<0.05);经ROC曲线分析发现血清HIF-1α、IL-4预测支气管扩张并发肺部感染患者预后不良的曲线下面积(AUC)分别达到0.795、0.823,IL-4+HIF-1α联合检测AUC高达0.911,高于各单项检测(P<0.05)。结论血清HIF-1α、IL-4均能有效评估、预测支气管扩张并发肺部感染患者的病情严重程度及预后发展,两指标联合检测的临床实用价值更高,对支气管扩张发病机制的研究有一定辅助意义。Objective To analyze the relationship between serum hypoxia-inducing factor 1α(HIF-1α)and interleukin-4(IL-4)and the severity and prognosis of patients with bronchiectasis complicated with pulmonary infection.Methods A total of 200 patients with bronchiectasis admitted to the hospital from April 2019 to May 2021 were selected and divided into an infected group(n=122)and an uninfected group(n=78)according to whether they were complicated with lung infection.The expression levels of HIF-1αand IL-4 in the two groups were compared and then divided into mild,moderate,and severe infections according to the severity of the infected group.The expression levels of HIF-1αand IL-4 in patients with different degrees of infection were analyzed,and the patients were divided into good prognosis and poor prognosis according to the prognosis of the infection group.The clinical data of patients with bronchiectasis complicated with pulmonary infection with different prognosis were compared,and the risk factors affecting the poor prognosis of patients with bronchiectasis complicated with pulmonary infection were analyzed by Logistic regression.The receiver operating characteristic(ROC)was used to analyze the prognostic value of serum HIF-1αand IL-4 in patients with bronchiectasis complicated with pulmonary infection.Results The levels of HIF-1αand IL-4 in the infected group were higher than those in the uninfected group(P<0.05).The levels of HIF-1αand IL-4 in patients with bronchiectasis with different degrees of infection showed that mild infection group<moderate infection group<severe infection group(P<0.05).There were significant differences in FEV1,mMRC score,HIF-1α,and IL-4 in patients with bronchiectasis complicated with pulmonary infection(P<0.05).Logistic regression analysis showed that the high expression of HIF-1αand IL-4 were the risk factors for poor prognosis of bronchiectasis complicated with pulmonary infection(P<0.05).ROC curve analysis showed that the AUC of serum HIF-1αand IL-4 to predict the poor prognos

关 键 词：血清缺氧诱导因子-1α 白介素-4 支气管扩张 病情严重程度 短期预后 相关性分析 

分 类 号：R562.22[医药卫生—呼吸系统] R563.1[医药卫生—内科学]