间苯三酚与黄体酮注射液联用对先兆流产患者妊娠结局的影响  

The effect of combined use of phloroglucinol and progesterone injection on pregnancy outcomes in patients with threatened miscarriage

作　　者：王俊娥 Wang Jun'e(Lijin County Maternal and Child Health Hospital,Dongying Shandong,257400,China)

机构地区：[1]利津县妇幼保健院,山东东营257400

出　　处：《中外女性健康研究》2024年第8期29-31,114,共4页Women＇s Health Research

摘　　要：目的:观察并分析对先兆流产患者应用间苯三酚与黄体酮注射液,对其妊娠结局的影响。方法:在利津县妇幼保健院共开展为期2年的研究,开始时间2022年3月,结束时间2024年2月,样本对象选定110例先兆流产患者,以治疗方法差异分组处理,即对照组(n=55)、观察组(n=55),分别予以黄体酮注射液、黄体酮注射液+间苯三酚。对比两组症状缓解时间、子宫动脉血流参数、孕激素水平、妊娠结局。结果:1)联合应用间苯三酚+黄体酮注射液后,观察组各项症状缓解时间均短于对照组,P<0.05。2)观察组子宫动脉血流各参数水平均低于对照组,P<0.05。3)观察组各项孕激素水平均高于对照组,P<0.05。4)观察组早产(16.36%)、流产(1.82%)发生率均低于对照组(25.45%、7.27%),足月妊娠率(81.82%)高于对照组(67.27%),差异不明显,P>0.05。结论:对先兆流产患者应用间苯三酚与黄体酮注射液,能够减轻患者临床症状,改善子宫动脉血流参数、孕激素水平,提高足月妊娠率,值得临床应用。Objective:To observe and analyze the effects of the use of injection of phloroglucinol and progesterone on pregnancy outcomes in patients with threatened miscarriage.Methods:A 2-year study was carried out in Lijin County Maternal and Child Health Hospital,starting from March 2022 and ending in February 2024.110 patients with threatened miscarriage were selected as the sample subjects,and were divided into two groups according to different treatment methods:the control group(n=55)and the observation group(n=55),receiving progesterone injection,progesterone injection and phloroglucinol,respectively.Compare the time of symptom relief,uterine artery blood flow parameters,progesterone levels and pregnancy outcomes between two groups.Results:1)After the combined application of phloroglucinol and progesterone injection,the relief time of various symptoms in the observation group was shorter than that in the control group,P<0.05。2)The levels of various parameters of uterine artery blood flow in the observation group were lower than those in the control group,P<0.05。3)The levels of various progesterones in the observation group were higher than those in the control group,P<0.05.4)The incidence rates of premature birth(9/55,16.36%)and miscarriage(1/55,1.82%)in the observation group were lower than those in the premature birth control group(14/55,25.45%)and miscarriage(4/55,7.27%),while the full-term pregnancy rate(45/55,81.82%)was higher than that in the control group(37/55,67.27%),and the difference was not significant,P>0.05.Conclusion:The application of phloroglucinol and progesterone injection to patients with threatened miscarriage can alleviate clinical symptoms,improve uterine artery blood flow parameters,progesterone levels,and increase full-term pregnancy rate.It is worth applying.

关 键 词：先兆流产 间苯三酚 黄体酮注射液 妊娠结局 

分 类 号：R714.21[医药卫生—妇产科学]