温肺通络经验方联合沙丁胺醇对慢性肺栓塞痰瘀互结证患者凝血因子X、VⅡ活性的影响  

Effect of Wenfei Tongluo Experience Prescription combined with salbutamol on the X、VⅡ activity of coagulation factors in patients with chronic pulmonary embolism and phlegm stasis syndrome

作　　者：陈慧玲 隆橘 罗茜 CHEN Huiling;LONG Ju;LUO Qian(Neijiang First People's Hospital,Neijiang Sichuan 641000,China)

机构地区：[1]内江市第一人民医院,四川内江641000

出　　处：《四川中医》2024年第7期106-110,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省医学科研课题(编号:S20054)。

摘　　要：目的:观察温肺通络经验方联合沙丁胺醇治疗慢性肺栓塞痰瘀互结证对患者凝血因子X、VⅡ活性的影响。方法:选取我院于2017年4月~2020年5月收治的慢性肺栓塞(中医辨证分型属痰瘀互结证)患者106例,参照其治疗方案进行均分组,对照组53例在抗凝、抗感染、化痰的基础上给予沙丁胺醇雾化吸入治疗,观察组53例在对照组基础上给予温肺通络经验方治疗。记录两组中医证候积分、炎症因子、凝血相关因子、肺动脉压、第一秒用力呼气容积占预计值(FVE1占预计值)的变化。结果:治疗后两组咳嗽、胸闷、呼吸困难、唇甲青紫、食欲不振及中医证候总积分等均大幅下降(P<0.05),且观察组治疗后各项中医证候总积分较对照组更低(P<0.05)。治疗后两组纤维蛋白原(FIB)、血小板计数(PLT)等均大幅提升,肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、凝血因子X、VⅡ的活性及D-二聚体(D-D)等均大幅下降(P<0.05),且观察组治疗后FIB、PLT较对照组更高,TNF-α、IL-1β、凝血因子X、VⅡ的活性及D-D较对照组更低(P<0.05)。治疗后两组FVE1占预计值大幅提升(P<0.05),肺动脉压大幅下降(P<0.05),且观察组治疗后FVE1占预计值较对照组更高,肺动脉压较对照组更低(P<0.05)。结论:温肺通络经验方联合沙丁胺醇治疗慢性肺栓塞痰瘀互结证可改善凝血相关因子的表达,减轻炎症反应和临床症状,提高肺功能。Objective:Effect of Wenfei Tongluo prescription combined with salbutamol on coagulation factor X、VⅡ activity of chronic pulmonary embolism phlegm and blood stasis syndrome was observed.Methods:A total of 106patients with chronic pulmonary embolism admitted to our hospital from April 2017to May 2020(syndrome of phlegm-stasis interassociation as the type of TCM syndrome differentiation)were selected and grouped according to their treatment plan.53patients in the control group were given atomized salbutamol inhalation therapy on the basis of anticoagulation,anti-infection and phlegm reduction,and 53patients in the observation group were given the empirical treatment of Wen Feitonglu decoction on the basis of the control group.The changes of TCM syndrome scores,inflammatory factors,coagulation related factors,pulmonary artery pressure and the predicted value of forced expiratory volume in the first second(FVE1)were recorded in the two groups.Results:After treatment,cough,chest tightness,dyspnea,blue lip nails,loss of appetite and the total score of TCM syndrome of the two groups were significantly decreased(P<0.05),and the total score of TCM syndrome of the observation group was lower than that of the control group(P<0.05).After treatment,fibrinogen(FIB)and platelet count(PLT)in both groups were significantly increased,while the activities of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),coagulation factor X,VⅡ and D-dimer(D-D)were significantly decreased(P<0.05).After treatment,FIB and PLT in observation group were higher than those in control group,and the activities of TNF-α,IL-1β,clotting factor X,VⅡ and D-D in observation group were lower than those in control group(P<0.05).After treatment,the predicted value of FVE1increased significantly(P<0.05),and the pulmonary artery pressure decreased significantly(P<0.05),and the predicted value of FVE1in the observation group was higher than that in the control group,and the pulmonary artery pressure was lower(P<0.05).Conclusion:In the treatment of c

关 键 词：温肺通络经验方 沙丁胺醇 慢性肺栓塞 痰瘀互结证 凝血因子 

分 类 号：R563.5[医药卫生—呼吸系统]