雷火灸、穴位贴敷治疗慢性肾脏病3~4期的疗效及对血清TGF-β1、Klotho、FGF23水平的影响  

Effect of lightning fire moxibustion and acupoint application on the serum level of TGF-β1,Klotho and FGF23 of chronic kidney disease Stage 3~4

作　　者：瞿晓密 朱云燕[2] 徐维 刘丹[1] QU Xiaomi;ZHU Yunyan;XU Wei(Nephrology Department,Nantong Traditional Chinese Medicine Hospital,Nantong Jiangsu 226001,China;Internal Medicine Department,Nantong Traditional Chinese Medicine Hospital,Nantong Jiangsu 226001,China)

机构地区：[1]南通市中医院肾内科,江苏南通226001 [2]南通市中医院内科,江苏南通226001

出　　处：《四川中医》2024年第7期187-190,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：南通市卫生健康委员会科研课题项目(MS2022037)。

摘　　要：目的:研究雷火灸、穴位贴敷治疗慢性肾脏病3~4期的疗效及对血清转化生长因子-β1(TGF-β1)、Klotho蛋白(Klotho)、成纤维生长因子23(FGF23)水平的影响。方法:2022年1月~2023年1月我院收治的慢性肾脏病3~4期患者92例,分为对照组与试验组,各46例,方法为随机数字表法。对照组予以常规西医治疗,试验组在对照组的基础上予以雷火灸、穴位贴敷治疗,两组均治疗2周。比较两组治疗2周后疗效,治疗前、治疗2周后血清TGF-β1、Klotho、FGF23水平、肾功能、免疫功能,治疗期间不良反应发生情况。结果:与对照组治疗2周后的总有效率(71.74%)比较,试验组总有效率更高(91.30%,P<0.05)。较治疗前,治疗2周后两组血清TGF-β1、FGF23、尿素氮(BUN)、血肌酐(Scr)水平,全血辅助性T细胞17(Th17)水平,24h尿蛋白定量降低,且试验组更低(P<0.05)。较治疗前,治疗2周后两组全血调节性T细胞(Treg)水平,血清免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、Klotho水平升高,且试验组更高(P<0.05)。治疗期间,两组不良反应发生率接近,均未影响继续治疗(P>0.05)。结论:雷火灸、穴位贴敷治疗慢性肾脏病3~4期的疗效较好,可改善肾功能、免疫功能,调节血清TGF-β1、Klotho、FGF23水平表达,降低肾脏损伤,安全性良好。Objective To study the curative effect of lightning fire moxibustion and acupoint application in the treatment of stage 3~4chronic kidney disease(CKD)and the effect on the serum levels of transforming growth factor-β1(TGF-β1),Klotho protein(Klotho)and fibroblast growth factor 23(FGF23).Methods From January 2022to January 2023,92patients with stage 3to 4chronic kidney disease in our hospital were divided into the control group and the experimental group,with 46cases in each group,using random number table method.The control group was treated with conventional western medicine,and the experimental group was treated with lightning fire moxibustion and acupoint application on the basis of the control group.Both groups were treated for 1month.The efficacy after 1month of treatment,serum levels of TGF-β1,Klotho,FGF23,renal function,immune function before treatment and after 1month of treatment,the occurrence of adverse reactions during treatment were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group(71.74%)after 1month of treatment(91.30%,P<0.05).Compared with before treatment,the serum levels of TGF-β1,FGF23,urea nitrogen(BUN),blood creatinine(Scr),whole blood helper T cell 17(Th17)and 24h urinary protein in 2groups decreased after 1month of treatment,and the experimental group was lower(P<0.05).Compared with before treatment,whole blood regulatory T cell(Treg)levels,serum levels of immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)and Klotho increased in two groups after 1month of treatment,and those in the experimental group were higher(P<0.05).During the treatment period,the incidence of adverse reactions was similar between the two groups,which did not affect the continuation of treatment(P>0.05).Conclusion The treatment of stage 3~4chronic kidney disease with lightning fire moxibustion and acupoint application had good efficacy,could improve renal function,immune function,regulate serum level of TGF-β1,Klotho,FG

关 键 词：慢性肾脏病3~4期 雷火灸 穴位贴敷 转化生长因子-β1 KLOTHO蛋白 成纤维生长因子23 

分 类 号：R246.1[医药卫生—针灸推拿学]