血清TNF-α、IL-17表达预测腰椎间盘突出症患者术后残留疼痛的价值  

Value of Serum TNF-αand IL-17 Expression in Predicting Residual Pain in Postoperative Patients with Lumbar Disc Herniation

作　　者：郭淼勇[1] GUO Miaoyong(Department of Orthopedics,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院骨科,河南郑州450014

出　　处：《河南医学研究》2024年第16期2935-2938,共4页Henan Medical Research

摘　　要：目的探讨血清肿瘤坏死因子(TNF-α)、白细胞介素-17(IL-17)表达预测腰椎间盘突出症患者术后残留疼痛的价值。方法回顾性收集2020年1月至2023年1月郑州大学第二附属医院收治的165例腰椎间盘突出症患者的临床资料,根据患者术后6个月时残留疼痛情况分为残留疼痛组(19例)和未残留疼痛组(146例)。术前检测患者血清TNF-α、IL-17水平,分析血清TNF-α、IL-17对腰椎间盘突出症患者术后残留疼痛的预测价值。结果两组纤维环损伤、TNF-α、IL-17水平差异有统计学意义(P<0.05);经logistic回归分析,结果显示,血清TNF-α、IL-17水平、纤维环损伤是腰椎间盘突出症患者术后残留疼痛发生的危险因素(OR>1,P<0.05);绘制受试者工作特征(ROC)曲线,结果显示,血清TNF-α、IL-17以及联合预测腰椎间盘突出症患者术后残留疼痛的曲线下面积(AUC)均>0.7,具有一定预测价值,且联合预测价值更高。结论血清TNF-α、IL-17高表达是腰椎间盘突出症患者术后残留疼痛的影响因素,且具有一定预测价值。Objective To explore the value of serum tumor necrosis factor(TNF-α)and interleukin-17(IL-17)expression in predicting postoperative residual pain in patients with lumbar disc herniation.Methods Clinical data of 165 patients with lumbar disc herniation admitted to the Second Affiliated Hospital of Zhengzhou University from January 2020 to January 2023 were retrospectively collected.Based on the residual pain situation of the patients at 6 months after surgery,they were divided into a residual pain group(19 cases)and a non-residual pain group(146 cases).Serum TNF-αand IL-17 levels of patients were tested before surgery.The predictive value of serum TNF-αand IL-17 for postoperative residual pain in patients with lumbar disc herniation was analyzed.Results There were differences in fibrous ring injury and the levels of TNF-αand IL-17 between the two groups(P<0.05).Through logistic regression analysis,the results showed that serum TNF-α,IL-17 levels and annulus fibrosus injury were risk factors for postoperative residual pain in patients with lumbar disc herniation(OR>1,P<0.05).The results of drawing receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)of serum TNF-α,IL-17,and their combined prediction of postoperative residual pain in patients with lumbar disc herniation were all greater than 0.7,indicating certain predictive value,and the combined predictive value was higher.Conclusion The high expression of serum TNF-αand IL-17 are the influencing factors of postoperative residual pain in patients with lumbar disc herniation,and has certain predictive value.

关 键 词：肿瘤坏死因子 白细胞介素-17 腰椎间盘突出症 残留疼痛 预测 

分 类 号：R687.3[医药卫生—骨科学]