血清GLP-1在非糖尿病不同严重程度动脉粥样硬化患者中的表达及其临床意义  

Expression and Clinical Significance of Serum GLP-1 in Non-diabetic Patients with Atherosclerosis of Different Severity

作　　者：覃艳 朱云峰[1] 翟倩倩[1] 王涛[1] 曹萌[1] QIN Yan;ZHU Yunfeng;ZHAI Qianqian;WANG Tao;CAO Meng(Ward 2,Department of Endocrinology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院内分泌科二病区,河南新乡453100

出　　处：《河南医学研究》2024年第16期2984-2988,共5页Henan Medical Research

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20220593)。

摘　　要：目的探讨血清胰高血糖素样肽-1(GLP-1)在非糖尿病不同严重程度动脉粥样硬化(AS)患者中的表达及其临床意义。方法按照1∶1∶1原则选取2022年4月至2023年9月新乡医学院第一附属医院收治的非糖尿病轻度AS患者55例(轻度组)、中度AS患者55例(中度组)、重度AS患者55例(重度组)。收集3组临床资料、血清GLP-1水平,单因素和logistic回归分析非糖尿病AS患者严重程度的影响因素,比较3组血清GLP-1水平;分析血清GLP-1水平与非糖尿病AS患者严重程度的相关性,分析血清GLP-1水平与非糖尿病AS患者严重程度影响因素的相关性。结果3组体重指数(BMI)、收缩压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)差异有统计学意义(P<0.05);logistic回归分析结果显示,BMI、收缩压≥140 mmHg、总胆固醇≥5.2 mmol·L^(-1)、甘油三酯≥1.7 mmol·L^(-1)、LDL-C≥3.4 mmol·L^(-1)是非糖尿病重度AS的独立危险因素,HDL-C≥1.0 mmol·L^(-1)是非糖尿病重度AS的独立保护因素(P<0.05);3组血清GLP-1水平比较:轻度组>中度组>重度组(P<0.05)。Spearman相关性分析显示,血清GLP-1水平与非糖尿病AS患者病情严重程度呈负相关(P<0.001);血清GLP-1水平与BMI、收缩压、总胆固醇、甘油三酯、LDL-C呈负相关,与HDL-C呈正相关(P<0.05)。结论非糖尿病不同严重程度AS患者血清GLP-1水平不同,血清GLP-1水平与AS患者病情严重程度密切相关。此外,血清GLP-1水平还与BMI、总胆固醇、收缩压、甘油三酯、LDL-C、HDL-C等具有相关性,血清GLP-1可为临床诊断、治疗非糖尿病不同严重程度AS患者提供参考。Objective To investigate the expression and clinical significance of serum glucagon-like peptide-1(GLP-1)in non-diabetic patients with atherosclerosis(AS)of different severity.Methods According to the principle of 1∶1∶1,55 non-diabetic patients with mild AS(mild group),55 patients with moderate AS(moderate group)and 55 patients with severe AS(severe group)were selected in the First Affiliated Hospital of Xinxiang Medical University from April 2022 to September 2023.Clinical data and serum GLP-1 level of the three groups were collected,and the influencing factors of the severity of non-diabetic AS patients were analyzed by univariate and logistic regression,and the serum GLP-1 level of the three groups was compared.The correlation of serum GLP-1 level with the severity of non-diabetic AS patients was analyzed,the correlation of serum GLP-1 level with the factors influencing of the severity of non-diabetic AS patients was analyzed.Results There were statistical differences in body mass index(BMI),systolic blood pressure,total cholesterol,triglyceride,high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)among three groups(P<0.05).Logistic regression analysis showed that BMI,systolic blood pressure≥140 mmHg,total cholesterol≥5.2 mmol·L^(-1),triglyceride≥1.7 mmol·L^(-1),LDL-C≥3.4 mmol·L^(-1)were independent risk factors for non-diabetic severe AS.HDL-C≥1.0 mmol·L^(-1)was an independent protective factor for non-diabetic severe AS(P<0.05).Serum GLP-1 level among three groups:mild group>moderate group>severe group(P<0.05).Spearman correlation analysis showed that serum GLP-1 level was negatively correlated with the severity of non-diabetic AS patients(P<0.001).Serum GLP-1 level was negatively correlated with BMI,systolic blood pressure,total cholesterol,triglyceride and LDL-C,and positively correlated with HDL-C(P<0.05).Conclusion The serum GLP-1 level in non-diabetic patients with AS of different severity is different,and the serum GLP-1 level is closely related to

关 键 词：非糖尿病 动脉粥样硬化 胰高血糖素样肽-1 病情严重程度 

分 类 号：R543.5[医药卫生—心血管疾病]