淋巴结靶向药物递送系统治疗移植排斥反应研究进展  

Research progress in lymph node targeted drug delivery system for transplantation rejection

作　　者：邱佳妮 宋怡姝 靳巧锋 白莹 谢明星[1] 王静[1] Qiu Jiani;Song Yishu;Jin Qiaofeng;Bai Ying;Xie Mingring;Wang Jing(Department of Ultrasound,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Clinical Research Center for Medical Imaging in Hubei Province,Hubei Province Key Laboratory of Molecular Imaging,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院超声医学科,湖北省影像医学临床医学研究中心,分子影像湖北省重点实验室,武汉430022

出　　处：《中华器官移植杂志》2024年第7期481-485,共5页Chinese Journal of Organ Transplantation

基　　金：国家自然科学基金(82171961,81801716)。

摘　　要：免疫抑制剂是临床上减轻器官移植排斥反应、改善受者术后短期临床结局最常用的治疗手段。然而全身使用免疫抑制剂会增加受者机会性感染的风险和恶性肿瘤的发生率。因此,将免疫抑制剂高效靶向递送至靶器官显得尤为重要。淋巴结是移植排斥反应激活的主要场所,近年来,靶向淋巴结的药物递送系统已在移植排斥反应治疗中发挥越来越重要的作用。本综述简要介绍了淋巴结在移植排斥反应中的作用机制,重点阐述了淋巴结靶向药物递送系统的构建及其在移植排斥反应中的应用进展,旨在将其应用于移植排斥反应的治疗以改善预后。Immunosuppressants are the most commonly used therapeutic means to reduce organ transplantation rejection and improve short-term clinical outcomes of patients after transplantation.However,systemic use of immunosuppressants increases the risk of opportunistic infections and the incidence of malignancies.Therefore,the efficient targeted delivery of immunosuppressants to target organs is particularly important.Lymph nodes are the main sites of transplant rejection activation.In recent years,drug delivery systems targeting lymph nodes have played an increasingly important role in the treatment of organ transplant rejection.This review briefly introduces the mechanism of action of lymph nodes in transplant rejection,and focuses on the construction of lymph node targeted drug delivery system and its application in transplant rejection,aiming to apply it in the treatment of transplant rejection toimprove patient outcomes.

关 键 词：淋巴结 移植排斥 靶向药物递送系统 免疫抑制剂 主动靶向 被动靶向 

分 类 号：R617[医药卫生—外科学]