Study on trifluoromethanesulfonic acid-promoted synthesis of daidzein: Process optimization and reaction mechanism  

作　　者：Hai Cao Haibin Yang Yanxiong Fang Yuandi Zeng Xiaolan Cai Jingjing Ma 

机构地区：[1]School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China [2]Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory),Jieyang 515200,China

出　　处：《Chinese Journal of Chemical Engineering》2024年第7期132-139,共8页中国化学工程学报（英文版）

基　　金：the Science and Technology Planning Project of Guangdong Province(2016B090934002);Guangdong Provincial Natural Science Foundation(2023A1515011640)for financial support.

摘　　要：Daidzein has been widely used in pharmaceuticals,nutraceuticals,cosmetics,feed additives,etc.Its preparation process and related reaction mechanism need to be further investigated.A cost-effective process for synthesizing daidzein was developed in this work.In this article,a two-step synthesis of daidzein(Friedel–Crafts acylation and[5+1]cyclization)was developed via the employment of trifluoromethanesulfonic acid(TfOH)as an effective promoting reagent.The effect of reaction conditions such as solvent,the amount of TfOH,reaction temperature,and reactant ratio on the conversion rate and the yield of the reaction,respectively,was systematically investigated,and daidzein was obtained in 74.0%isolated yield under optimal conditions.Due to the facilitating effect of TfOH,the Friedel–Crafts acylation was completed within 10 min at 90℃ and the[5+1]cyclization was completed within 180 min at 25℃.In addition,a possible reaction mechanism for this process was proposed.The results of the study may provide useful guidance for industrial production of daidzein on a large scale.

关 键 词：SYNTHESIS Optimal design Chemical processes Reaction mechanism 

分 类 号：TQ28[化学工程—有机化工]