中药配方颗粒中重金属及有害元素残留量测定  

Determination of Heavy Metal and Harmful Element Residues in Chinese Medicine Formulae Granules

作　　者：杨春艳 刘志海 毛盘线 YANG Chunyan;LIU Zhihai;MAO Panxian(Qianxinan Inspection and Testing Centre,Xingyi 562400,China)

机构地区：[1]黔西南州检验检测中心,贵州兴义562400

出　　处：《品牌与标准化》2024年第5期41-43,共3页

摘　　要：目的:建立电感耦合等离子体质谱(ICP-MS)法对中药配方颗粒中铅、镉、砷、汞、铜5种重金属及有害元素残留量进行测定,考察中药配方颗粒中重金属及有害元素的残留量,并进行分析。结果:5种重金属元素的标准曲线R在0.9980~1.0000之间,线性关系良好。平均加标回收率为90.8%~99.8%,RSD在2.6%~5.0%之间。结论:通过对49批次中药配方颗粒测定结果分析,样品存在不同程度的重金属污染。因此,应加强对残留在中药配方颗粒中的重金属进行检测,严格控制原料来源和生产过程,保证人民群众的用药安全。Objective:To establish an inductively coupled plasma mass spectrometry(ICP-MS)method for the determination of residual amounts of five heavy metals and harmful elements,including lead,cadmium,arsenic,mercury,and copper,in Chinese herbal formula granules,and to investigate and analyze the residual levels of heavy metals and harmful elements in these granules.Results:The standard curves for the five heavy metal elements had R values ranging from 0.9980 to 1.0000,indicating good linearity.The average spiked recovery rates were between 90.8%and 99.8%,with relative standard deviations(RSD)ranging from 2.6%to 5.0%.Conclusion:Analysis of the measurement results from 49 batches of Chinese herbal formula granules revealed varying degrees of heavy metal contamination in the samples.Therefore,it is necessary to strengthen the detection of heavy metals in Chinese herbal formula granules,strictly control the sources of raw materials and the production process,to ensure the safety of medication for the public.

关 键 词：中药配方颗粒 电感耦合等离子体质谱 重金属 有害元素 

分 类 号：R286.0[医药卫生—中药学]