腹膜透析治疗心力衰竭利尿剂抵抗患者的临床应用  

Clinical application of peritoneal dialysis in the treatment of heart failure patients with diuretic resistance

作　　者：成水芹 余乐 张志宏 俞雨生 Cheng Shuiqin;Yu Le;Zhang Zhihong;Yu Yusheng(Department of Nephrology,Jinling Hosptial,Nanjing University School of Medicine,National Clinical Research Center of Kidney Disease,Nanjing 210016,China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院)肾内科国家肾脏疾病临床医学研究中心,南京210016

出　　处：《中华肾脏病杂志》2024年第7期573-577,共5页Chinese Journal of Nephrology

基　　金：国家卫生和计划生育委员会重点项目(YYS2016001)。

摘　　要：心力衰竭(heart failure,HF)目前有很多新的治疗方法,但利尿剂抵抗的HF患者病情复杂、严重,其治疗具有一定挑战性。HF患者发生利尿剂抵抗的主要机制为各种因素导致机体对利尿剂的反应降低、水钠潴留,腹膜透析因其具有超滤、排钠、改善心功能、保护残余肾功能等优势是治疗HF利尿剂抵抗患者的一种安全有效的选择。该文简介腹膜透析治疗HF利尿剂抵抗患者的理论基础和临床实践,以期为临床提供指导。There are numerous novel therapies available for heart failure(HF)nowadays,but the condition of HF patients with diuretic resistance is notably complicated and severe,and its treatment is challenging.The main mechanisms of diuretic resistance in HF patients were the decrease of body's response to diuretics due to various reasons,and the retention of water and sodium.Peritoneal dialysis stands out as a safe and effective choice for the treatment of diuretic resistance in HF patients because of its advantages of ultrafiltration,sodium excretion,improvement of cardiac function,and preservation of residual renal function.This review outlines the rationale and clinical application of peritoneal dialysis in treating HF patients with diuretic resistance,to provide clinical guidance.

关 键 词：腹膜透析 心力衰竭 利尿药 心功能 肾功能 

分 类 号：R541.6[医药卫生—心血管疾病] R692.5[医药卫生—内科学]