水稻“混血杂交”群体揭示遗传互作奥秘  

The Rice"hybrid"Population Reveals the Mysteries of Genetic Interaction

作　　者：王淏 钦鹏[1,2] 李仕贵 Hao Wang;Peng Qin;Shigui Li(Rice Research Institute,Sichuan Agricultural University,Chengdu 611130,China;State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China,Chengdu 611130,China)

机构地区：[1]四川农业大学水稻研究所,成都611130 [2]西南作物基因资源发掘与利用国家重点实验室,成都611130

出　　处：《植物学报》2024年第4期529-532,共4页Chinese Bulletin of Botany

基　　金：国家自然科学基金委区域联合基金(No.U22A20465)。

摘　　要：基因互作与表型的内在关系是生命科学研究的关键问题,大部分表型受多基因协同控制,除加性效应外还存在显性和上位性等复杂遗传效应。最近一项研究构建了包含18421个永久株系的水稻“混血杂交”群体,成功鉴定到控制16个农艺性状的96个高置信候选基因,通过分析基因间上位性效应,构建了包含19个枢纽基因的遗传互作网络,揭示出基因间潜在的互作效应,发现170个“掩蔽”型上位互作对。该工作建立了作物遗传学研究的新范式,且为水稻(Oryzasativa)遗传研究提供了重要数据和材料资源,极大地加速了重要性状相关基因的挖掘,推动了数量性状基因遗传互作的功能解析,为分子设计育种奠定了理论基础。Revealing the intrinsic relationship between gene interactions and phenotypes is a key issue in life science research.Most phenotypes are controlled by multiple genes in a coordinated manner,exhibiting complex genetic effects such as dominance and epistasis in addition to additive effects.In a recent study,a“hybrid”population of rice containing 18421 recombinant inbred lines was constructed,successfully identifying 96 high-confidence candidate genes controlling 16 agronomic traits.The study analyzed the epistatic effects among genes,constructed a genetic interaction network consisting of 19 hub genes,revealed potential interactions among genes,and discovered 170“masking”epistatic interac-tions.This research provides important data and material resources for genetic studies in rice,establishes a new para-digm for crop genetics research,greatly accelerates the discovery of genes related to important traits,advances the functional analysis of quantitative trait gene interactions,and provides genetic resources and theoretical support for mole-cular breeding.

关 键 词：“混血杂交”群体 数量性状 遗传多效性 上位性 

分 类 号：S511[农业科学—作物学]