Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy  

作　　者：Xueqiang Peng Jianjun Fang Chuyuan Lou Liang Yang Shaobo Shan Zixian Wang Yutong Chen Hangyu Li Xuexin Li 

机构地区：[1]Department of General Surgery,The Fourth Affiliated Hospital,China Medical University,Shenyang 110032,China [2]Department of Ophthalmology,Xi’an People’s Hospital(Xi’an Fourth Hospital),Xi’an 710004,China [3]Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 10050,China [4]Department of Medical Oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center of Cancer Medicine,Guangzhou 510060,China [5]Department of Pathology,Medical College,Jinan University,Guangzhou 510632,China [6]Department of Physiology and Pharmacology,Karolinska Institutet,Stockholm SE-17177,Sweden

出　　处：《Acta Pharmaceutica Sinica B》2024年第8期3432-3456,共25页药学学报（英文版）

基　　金：supported by grants from Karolinska Institute Network Medicine Global Alliance Collaborative Grant(C24401073,Sweden);China Postdoctoral Science Foundation(2021M703602);Natural Science Foundation of Liaoning Province(2022-BS-137,China).

摘　　要：The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune system.However,the challenge of practical and precise targeting of malignant cells persists.To address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface modification.This comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic effectiveness.Moreover,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic modalities.Finally,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.

关 键 词：Engineered nanoparticles Cancer immunotherapy Drug delivery Bloodebrain barrier Tumor-barrier NANOMEDICINE NANOMATERIAL Cancer 

分 类 号：R943[医药卫生—药剂学]