DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment  

作　　者：Miao Mao Zhe Pu Yuanqing Zhang 

机构地区：[1]School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510006,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第8期3777-3779,共3页药学学报（英文版）

基　　金：support from the National Natural Science Foundation of China(82072087,31970893,32270976);funding by Science and Technology Projects in Guangzhou(202206010087,China).

摘　　要：Recently,a work jointly studied by Ling Li and coworkers1 was published in Nature Materials,describing a reconfigurable DNA origami nanodevice designed to regulate CD95 death-inducing signaling of immune cells.The researchers utilized the DNA origami nanodevice to establish selective local immune tolerance and demonstrated its ability to alleviate rheumatoid arthritis(RA)in the inflamed synovial tissue of mice without causing any obvious side effects(Fig.1).This approach presents a novel idea for the development of drug interventions involving ligandreceptor interactions.

关 键 词：DNA origami Rheumatoid arthritis CD95 death-inducing signaling DNA nanostructure Drug delivery Receptoreligand interaction Cell signaling Drug intervention 

分 类 号：R593.22[医药卫生—内科学]