妊娠合并梅毒感染流行学特征及不良妊娠结局分析  

Epidemiological characteristics of pregnancy complicated with syphilis infection and analysis of adverse pregnancy outcomes

作　　者：唐静 王美丽 窦文莉 林河 豆银霞 禹瑞 TANG Jing;WANG Meili;DOU Wenli;LIN He;DOU Yinxia;YU Rui(Department of Nursing,Zhengzhou Shuqing Medical College,Zhengzhou 450064,China;Department of Obstetrics,The Second Affiliated Hospital of Zhengzhou University;Department of Anesthesiology,Maternal and Child Health Hospital of Henan Province)

机构地区：[1]郑州澍青医学高等专科学校护理系,河南郑州450064 [2]郑州大学第二附属医院产科 [3]河南省妇幼保健院麻醉科

出　　处：《中国病原生物学杂志》2024年第9期1061-1065,共5页Journal of Pathogen Biology

摘　　要：目的探析本地区妊娠合并梅毒感染流行学特征及不良妊娠结局发生情况。方法回顾性分析2021-2023年郑州地区5家综合性医院接诊的112例妊娠合并梅毒感染患者临床资料,分析患者临床特征、发病时间、发病年龄等流行学特征,以是否发生不良妊娠结局将患者进行分组,对比分析妊娠合并梅毒感染发生不良妊娠结局的影响因素。结果112例妊娠合并梅毒感染患者中,69.64%患者为首次梅毒感染,66.96%患者梅毒感染分期为隐性梅毒,67.86%患者非梅毒螺旋体抗原血清学检测滴度≤1∶4,71.43%患者确诊感染时期为孕期,75%患者采用青霉素治疗,53.57%患者性伴侣未进行梅毒检测,50.89%患者居住地为城市,40.18%患者文化程度为初中,41.96%患者婚姻状况为未婚,69.64%患者未行产前保健检查,29.46%患者合并贫血,8.93%患者合并病毒性肝炎,15.18%患者合并妊娠期高血压,4.46%患者合并妊娠期糖尿病,2.68%患者合并淋病。2021、2022和2023年妊娠合并病毒感染患者分别为30、28和54例。2021-2023年各月份均有妊娠合并梅毒感染患者,每年检出人数主要集中于5~9月,7月份检出人数最多。2021-2023年每年检出人数主要集中于26~40岁,2021、2022和2023年分别主要集中于26~30岁、31~35岁、26~30岁。112例妊娠合并梅毒感染患者中,23例发生不良妊娠结局,发生率20.54%(23/112),2021、2022和2023年不良妊娠结局发生率分别为33.33%(10/30)、28.57%(8/28)、9.26%(5/54),不同年份患者不良妊娠结局发生率差异有统计学意义(χ^(2)=8.327,P<0.05)。不同年龄、不同产次、是否有梅毒既往感染史、不同梅毒感染分期、是否接受治疗的患者不良妊娠结局发生率差异有统计学意义(P<0.05),不同文化程度、不同婚姻状况、性伴侣梅毒检测情况差异无统计学意义(P>0.05)。结论本地区妊娠合并梅毒感染患者临床特征主要为具有梅毒既往感染病史、隐性梅毒感染,每年Objective To explore the epidemiological characteristics of pregnancy complicated with syphilis infection and the occurrence of adverse pregnancy outcomes in the local area.Methods A retrospective analysis was conducted on 112 pregnant women with syphilis infection admitted to 5 comprehensive hospitals in Zhengzhou from 2021 to 2023.A retrospective analysis was conducted on the clinical data of 112 patients with pregnancy complicated with syphilis infection who were admitted to 5 comprehensive hospitals in Zhengzhou area from 2021 to 2023.The epidemiological characteristics such as clinical features,onset time and age of onset of the patients were analyzed.The patients were grouped according to whether adverse pregnancy outcomes occurred,and the influencing factors of adverse pregnancy outcomes in pregnancy complicated with syphilis infection were compared and analyzed.Results Of 112 pregnant women with syphilis infection,69.64%were first syphilis infection,66.96%were asymptomatic syphilis infection,67.86%were non syphilis spirochete antigen serological test titers≤1∶4,71.43%were diagnosed during pregnancy,75%were treated with penicillin,53.57%were not tested for syphilis by their sexual partners,50.89%were living in cities,40.18%were junior high school educated,41.96%were unmarried,69.64%were not checked for prenatal health care,29.46%were complicated with anemia,8.93%were complicated with viral hepatitis,15.18%were complicated with pregnancy hypertension,4.46%patients were complicated with gestational diabetes,2.68%patients were complicated with gonorrhea.The number of patients with pregnancy complicated by viral infection was 30,28 and 54 respectively in 2021,2022 and 2023.From 2021 to 2023,there were pregnant women with syphilis infection in each month,and the number of detected cases was mainly concentrated from May to September each year,with the highest number detected in July.The number of detected cases each year was mainly concentrated between the ages of 26 to 40 from 2021 to 2023,and 26 to 30 in 2

关 键 词：妊娠合并梅毒 流行性特征 不良妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学] R759.1[医药卫生—临床医学]