Whole-genome resequencing of Hu sheep identifies candidate genes associated with agronomic traits  

作　　者：Liming Zhao Lvfeng Yuan Fadi Li Xiaoxue Zhang Huibin Tian Zongwu Ma Deyin Zhang Yukun Zhang Yuan Zhao Kai Huang Xiaolong Li Jiangbo Cheng Dan Xu Xiaobin Yang Kunchao Han Xiuxiu Weng Weimin Wang 

机构地区：[1]State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems,Key Laboratory of Grassland Livestock Industry Innovation,Ministry of Agriculture and Rural Affairs,Engineering Research Center of Grassland Industry,Ministry of Education,College of Pastoral Agriculture Science and Technology,Lanzhou University,Lanzhou,Gansu 730020,China [2]Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou,Gansu 730046,China [3]College of Animal Science and Technology,Gansu Agricultural University,Lanzhou,Gansu 730070,China

出　　处：《Journal of Genetics and Genomics》2024年第8期866-876,共11页遗传学报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2021YFD1300901,2022YFD1302000);National Natural Science Foundation of China(32260818,31960653)。

摘　　要：The phenotypic diversity resulting from artificial or natural selection of sheep has made a significant contribution to human civilization.Hu sheep are a local sheep breed unique to China with high reproductive rates and rapid growth.Genomic selection signatures have been widely used to investigate the genetic mechanisms underlying phenotypic variation in livestock.Here,we conduct whole-genome sequencing of 207 Hu sheep and compare them with the wild ancestors of domestic sheep(Asiatic mouflon)to investigate the genetic characteristics and selection signatures of Hu sheep.Based on six signatures of selection approaches,we detect genomic regions containing genes related to reproduction(BMPR1B,BMP2,PGFS,CYP19,CAMK4,GGT5,and GNAQ),vision(ALDH1A2,SAG,and PDE6B),nervous system(NAV1),and immune response(GPR35,SH2B2,PIK3R3,and HRAS).Association analysis with a population of 1299 Hu sheep reveals that those missense mutations in the GPR35(GPR35 g.952651 A>G;GPR35 g.952496 C>T)and NAV1(NAV1 g.84216190 C>T;NAV1 g.84227412 G>A)genes are significantly associated(P<0.05)with immune and growth traits in Hu sheep,respectively.This research offers unique insights into the selection characteristics of Hu sheep and facilitates further genetic improvement and molecular investigations.

关 键 词：Hu sheep Whole-genome resequencing Selection signature GPR35 NAV1 Single nucleotide polymorphism 

分 类 号：S828[农业科学—畜牧学]