The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation  

作　　者：Yuxin Kang Yilin Liang Fengting Fan Hojjat Asadollahpour Nanaei Chunna Cao Yu Jiang Xianyong Lan Chuanying Pan Ran Li 

机构地区：[1]College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China [2]Key Laboratory of Livestock Biology,Northwest A&F University,Yangling,Shaanxi 712100,China [3]Department of Animal Science,Fars Agricultural and Natural Resources Research and Education Center,Agricultural Research,Education&Extension Organization(AREEO),Fars,Iran Author links open overlay panel

出　　处：《Journal of Genetics and Genomics》2024年第8期877-879,共3页遗传学报（英文版）

基　　金：supported by the Sci-Tech Innovation 2030 Agenda(2022ZD0401403);Natural Science Basic Research Plan in Shaanxi Provine of China(2023-JC-YB-157);supported by the National Natural Science Foundation of China(U21A20120);Shaanxi Livestock and Poultry Breeding Double-chain Fusion Key Project(2022GD-TSLD-46-0401).

摘　　要：Hemoglobin is responsible for transporting oxygen from the lungs to body tissues.Structurally,this protein is a tetramer composed of two a-globin chains and twoβ-globin chains.In sheep,the β-globin locus is of particular interest because it contains two different haplotypes,namely haplotype A(hap A)and hap B,which differ in length by more than 30 kb and do not undergo recombination with each other due to low sequence similarity(Bauer and Jung,1975;Jiang et al.,2015).The two haplotypes also differ in gene content with hap A possessing two clusters of hemoglobin gene families and hap B possessing only one(Aguiletam et al.,2004),which implies differentiation in their functional roles.Hap A was speculated to be associated with high-altitude adaptation in sheep(Hu et al.,2019).

关 键 词：CHAINS ALTITUDE SIMILARITY 

分 类 号：S562[农业科学—作物学]