少棘巨蜈蚣中二个新含氮芳香苷的分离鉴定  

Isolation and identification of two nitrogen-containing aromatic glycosides from Scolopendra subspinipes mutilans

作　　者：杨书平 胡缤元 程永现 YANG Shu-ping;HU Bin-yuan;CHENG Yong-xian(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Institute for Inheritancebased Innovation of Chinese Medicine,Shenzhen University Medical School,Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics,Shenzhen 518060,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]深圳大学医学部药学院,中医药守正创新研究院,广东省中药有效成分与肠道微生物组学重点实验室,广东深圳518060

出　　处：《药学学报》2024年第8期2283-2287,共5页Acta Pharmaceutica Sinica

基　　金：深圳市高层次人才团队项目(孔雀团队).

摘　　要：通过大孔树脂、MCI gel CHP 20P、ODS-A-HG、Sephadex LH-20等色谱方法反复柱层析,并结合TLC和反相HPLC色谱方法,从药用动物少棘巨蜈蚣醇提物的乙酸乙酯部位中分离得到3个苷类和2个肽类化合物。借助UV、1D/2D NMR和HR-ESI-MS等现代波谱技术分别鉴定为colosides A和B (1和2)、吲哚-3-甲酰基-β-D-吡喃葡萄糖苷(3)、橙黄胡椒酰胺(4)和环(L-苯丙-L-缬)(5)。其中1和2为新化合物、3和4为首次从蜈蚣中分到的化合物。Using column chromatography methods including the macroporous adsorbent resin,MCI gel CHP 20P,ODS-A-HG,Sephadex LH-20,combined with chromatographic separation methods such as TLC and reversedphase HPLC,three glycosides(1-3)and two peptides including two new compounds were isolated from the ethanol extract of arthropod Scolopendra subspinipes mutilans.Their structures were identified as colosides A and B(1 and 2),3,4-dihydroxyquinoline-4-O-β-D-glucopyranoside(3),aurantiamide(4),cyclo(L-phe-L-val)(5)by UV,NMR and HR-ESI-MS spectroscopic techniques.

关 键 词：蜈蚣科 少棘巨蜈蚣 化学成分 芳香苷 吲哚苷 肽类 

分 类 号：R284[医药卫生—中药学]