益母草中一个新的苯乙醇苷  

A new phenylethanol glycoside from Leonurus japonicus

作　　者：邹娜 刘娟[1,3] 蒙春旺 刘娟汝 周勤梅 彭成 熊亮[1,2,3] ZOU Na;LIU Juan;MENG Chun-wang;LIU Juan-ru;ZHOU Qin-mei;PENG Cheng;XIONG Liang(State Key Laboratory of Southwestern Chinese Medicine Resources,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Medical Technology,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Innovation Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院,西南特色中药资源国家重点实验室,四川成都611137 [2]成都中医药大学医学技术学院,四川成都611137 [3]成都中医药大学,西南特色药材创新药物成分研究所,四川成都611137 [4]成都中医药大学中医药创新研究院,四川成都611137

出　　处：《药学学报》2024年第8期2300-2304,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金面上项目(81872991);国家自然科学基金联合基金重点支持项目(U19A2010);国家自然科学基金优秀青年科学基金项目(82022072)。

摘　　要：采用大孔吸附树脂、硅胶、ODS、葡聚糖凝胶等色谱填料,运用柱色谱、半制备液相色谱等分离技术,对益母草(Leonurus japonicus Houtt.)乙醇提取物的正丁醇部位进行分离纯化,利用高分辨质谱、红外、核磁共振等波谱技术和酸水解反应鉴定化合物的结构。从益母草中分离得到6个苯乙醇苷类化合物,分别为leonoside G (1)、leonoside E (2)、leonoside B (3)、leonoside F (4)、cistanoside G (5)、红景天苷(6),其中化合物1为从益母草中获得的新的苯乙醇苷类化合物。The column chromatography and semi-preparative liquid phase chromatography with several chromatographic packing materials,including macroporous adsorbent resin,silica gel,ODS,and Sephadex LH-20,were used for the separation and purification of n-butanol-soluble portion of ethanol extract of Leonurus japonicus Houtt.The structures of isolates were identified by HR-MS,IR,NMR,and acid hydrolysis reaction.Six phenylethanol glycosides were obtained from L.japonicus and identified as leonoside G(1),leonoside E(2),leonoside B(3),leonoside F(4),cistanoside G(5),and salidroside(6).Compound 1 is a new phenylethanol glycoside.

关 键 词：益母草 化学成分 苯乙醇苷 分离鉴定 

分 类 号：R284[医药卫生—中药学]