细胞自噬在局灶节段性肾小球硬化中的研究进展  

Research advances of cell autophagy in focal segmental glomerulosclerosis

作　　者：张敏[1] 米焱[2] 王彩丽[2] Zhang Min;Mi Yan;Wang Cai-li(Department of Internal Medicine,First Affiliated Hospital,Baotou Medical College,Inner Mongolia University of Science&Technology,Baotou 014010,China;Department of Nephrology,First Affiliated Hospital,Baotou Medical College,Inner Mongolia University of Science&Technology,Baotou 014010,China)

机构地区：[1]内蒙古科技大学包头医学院包头医学院第一附属医院内科,包头014010 [2]内蒙古科技大学包头医学院包头医学院第一附属医院肾内科,包头014010

出　　处：《临床肾脏病杂志》2024年第8期677-680,共4页Journal Of Clinical Nephrology

基　　金：内蒙古自治区自然科学基金(2021MS08008)。

摘　　要：局灶节段性肾小球硬化(focal segmental glomerulosclerosis,FSGS)是伴有大量蛋白尿的临床病理综合征,以局灶肾小球硬化和足细胞足突消失为特征。现研究已证实足细胞损伤是FSGS发病的核心,且越来越多的研究表明氧化应激、炎症、近端小管上皮细胞(proximal tubule epithelial cells,PTECs)和肾小球内皮细胞(glomerular endothelial cells,GECs)的紊乱有助于FSGS的发展。近年来自噬在诸多研究领域备受瞩目,许多证据表明自噬在FSGS中发挥着重要的调控作用,这也为FSGS的治疗提供了一个新靶点,本文就自噬及其在FSGS中的作用做一综述。As a clinical pathological syndrome,focal segmental glomerulosclerosis(FSGS)is characterized by focal glomerulosclerosis,disappearance of podocyte processes and massive proteinuria.Current researches have confirmed that foot cell injury is a central pathogenetic cause of FSGS.And a growing number of studies have demonstrated that oxidative stress,inflammation and disruption of proximal tubular epithelial cells(PTECs)and glomerular endothelial cells(GECs)contribute to the development of FSGS.In recent years,autophagy has attracted greater attention in various research fields.It proved that autophagy plays an important regulatory role in FSGS,And it provided a novel therapeutic target FSGS.This review focused upon autophagy and its roles in FSGS.

关 键 词：局灶节段性肾小球硬化 自噬 mTORC1 ATG 

分 类 号：R692[医药卫生—泌尿科学]